Influence of IL1B (rs16944) and IL1R2 (rs4141134) polymorphisms on aggressiveness and prognosis of cutaneous melanoma.
0.01
3
We found that IL1R2 rs4141134 GG genotype was more common in patients with nodular subtype 49.1% vs. 29.8%, P = 0.01 and the frequency of IL1R2 rs4141134 GG or GA was higher in patients with Clark levels III-V 87.4% vs. 75.8%, P = 0.04.
Influence of IL1B (rs16944) and IL1R2 (rs4141134) polymorphisms on aggressiveness and prognosis of cutaneous melanoma.
0.04
3
We found that IL1R2 rs4141134 GG genotype was more common in patients with nodular subtype 49.1% vs. 29.8%, P = 0.01 and the frequency of IL1R2 rs4141134 GG or GA was higher in patients with Clark levels III-V 87.4% vs. 75.8%, P = 0.04.
Influence of IL1B (rs16944) and IL1R2 (rs4141134) polymorphisms on aggressiveness and prognosis of cutaneous melanoma.
0.03
3
Patients with IL1R2 rs4141134 GG or GA genotypes presented lower PFS hazard ratio: 3.12, 95% confidence interval, 1.10-8.79, P = 0.03 when compared with AA genotype, supported by OSskcm results.
Skin pigmentation polymorphisms associated with increased risk of melanoma in a case-control sample from southern Brazil.
2020-11-09
2.31
2.094
1
Single nucleotide polymorphisms SNPs in pigmentation genes have been described in melanoma risk modulation, but knowledge in the field is still limited.In a case-control approach 107 cases and 119 controls, we investigated the effect of four pigmentation gene SNPs TYR rs1126809, HERC2 rs1129038, SLC24A5 rs1426654, and SLC45A2 rs16891982 on melanoma risk in individuals from southern Brazil using a multivariate logistic regression model and multifactor dimensionality reduction MDR analysis.Two SNPs were associated with an increased risk of melanoma in a dominant model: rs1129038AA and rs1426654AA [OR = 2.094 95% CI: 1.106-3.966, P = 2.3 10<sup>- 2</sup> and OR = 7.126 95% CI: 1.873-27.110, P = 4.0 10<sup>- 3</sup>, respectively].
Skin pigmentation polymorphisms associated with increased risk of melanoma in a case-control sample from southern Brazil.
2020-11-09
-2.0
7.126
1
Single nucleotide polymorphisms SNPs in pigmentation genes have been described in melanoma risk modulation, but knowledge in the field is still limited.In a case-control approach 107 cases and 119 controls, we investigated the effect of four pigmentation gene SNPs TYR rs1126809, HERC2 rs1129038, SLC24A5 rs1426654, and SLC45A2 rs16891982 on melanoma risk in individuals from southern Brazil using a multivariate logistic regression model and multifactor dimensionality reduction MDR analysis.Two SNPs were associated with an increased risk of melanoma in a dominant model: rs1129038AA and rs1426654AA [OR = 2.094 95% CI: 1.106-3.966, P = 2.3 10<sup>- 2</sup> and OR = 7.126 95% CI: 1.873-27.110, P = 4.0 10<sup>- 3</sup>, respectively].
Skin pigmentation polymorphisms associated with increased risk of melanoma in a case-control sample from southern Brazil.
2020-11-09
4.01
1
Single nucleotide polymorphisms SNPs in pigmentation genes have been described in melanoma risk modulation, but knowledge in the field is still limited.In a case-control approach 107 cases and 119 controls, we investigated the effect of four pigmentation gene SNPs TYR rs1126809, HERC2 rs1129038, SLC24A5 rs1426654, and SLC45A2 rs16891982 on melanoma risk in individuals from southern Brazil using a multivariate logistic regression model and multifactor dimensionality reduction MDR analysis.Two SNPs were associated with an increased risk of melanoma in a dominant model: rs1129038AA and rs1426654AA [OR = 2.094 95% CI: 1.106-3.966, P = 2.3 10<sup>- 2</sup> and OR = 7.126 95% CI: 1.873-27.110, P = 4.0 10<sup>- 3</sup>, respectively].
Skin pigmentation polymorphisms associated with increased risk of melanoma in a case-control sample from southern Brazil.
2020-11-09
-3.0
1
Single nucleotide polymorphisms SNPs in pigmentation genes have been described in melanoma risk modulation, but knowledge in the field is still limited.In a case-control approach 107 cases and 119 controls, we investigated the effect of four pigmentation gene SNPs TYR rs1126809, HERC2 rs1129038, SLC24A5 rs1426654, and SLC45A2 rs16891982 on melanoma risk in individuals from southern Brazil using a multivariate logistic regression model and multifactor dimensionality reduction MDR analysis.Two SNPs were associated with an increased risk of melanoma in a dominant model: rs1129038AA and rs1426654AA [OR = 2.094 95% CI: 1.106-3.966, P = 2.3 10<sup>- 2</sup> and OR = 7.126 95% CI: 1.873-27.110, P = 4.0 10<sup>- 3</sup>, respectively].
Skin pigmentation polymorphisms associated with increased risk of melanoma in a case-control sample from southern Brazil.
2020-11-09
310.0
0.081
2
SNP rs16891982CC was associated with a lower risk to melanoma development in a log-additive model when the allele C was inherited [OR = 0.081 95% CI: 0.008-0.782, P = 3 10<sup>- 2</sup>].
Skin pigmentation polymorphisms associated with increased risk of melanoma in a case-control sample from southern Brazil.
2020-11-09
-2.0
2
SNP rs16891982CC was associated with a lower risk to melanoma development in a log-additive model when the allele C was inherited [OR = 0.081 95% CI: 0.008-0.782, P = 3 10<sup>- 2</sup>].
Skin pigmentation polymorphisms associated with increased risk of melanoma in a case-control sample from southern Brazil.
2020-11-09
310.0
1
In addition, MDR analysis showed that the combination of the rs1426654AA and rs16891982GG genotypes was associated with a higher risk for melanoma P = 3 10<sup>- 3</sup>, with a redundant effect.These results contribute to the current knowledge and indicate that epistatic interaction of these SNPs, with an additive or correlational effect, may be involved in modulating the risk of melanoma in individuals from a geographic region with a high incidence of the disease.
Skin pigmentation polymorphisms associated with increased risk of melanoma in a case-control sample from southern Brazil.
2020-11-09
-3.0
1
In addition, MDR analysis showed that the combination of the rs1426654AA and rs16891982GG genotypes was associated with a higher risk for melanoma P = 3 10<sup>- 3</sup>, with a redundant effect.These results contribute to the current knowledge and indicate that epistatic interaction of these SNPs, with an additive or correlational effect, may be involved in modulating the risk of melanoma in individuals from a geographic region with a high incidence of the disease.
Heritable genetic variants in key cancer genes link cancer risk with anthropometric traits.
2020-06-26
7.62
1.36
10
Of particular interest, we identify a previously unrecognised strong association between the rs78378222[C] SNP in the 3' untranslated region 3'-UTR of TP53 and both increased risk for developing non-melanomatous skin cancer OR=1.36 95% 1.31 to 1.41, adjusted p=7.62E<sup>-63</sup>, brain malignancy OR=3.12 2.22 to 4.37, adjusted p=1.43E<sup>-12</sup> and increased standing height adjusted p=2.18E<sup>-24</sup>, beta=0.073±0.007, lean body mass adjusted p=8.34E<sup>-37</sup>, beta=0.073±0.005 and basal metabolic rate adjusted p=1.13E<sup>-31</sup>, beta=0.076±0.006, thus offering a novel genetic link between these anthropometric traits and cancer risk.Our results clearly demonstrate that heritable variants in key cancer genes can associate with both differential cancer risk and anthropometric traits in the general population, thereby lending support for a genetic basis for linking these human phenotypes.
Heritable genetic variants in key cancer genes link cancer risk with anthropometric traits.
2020-06-26
-63.0
3.12
10
Of particular interest, we identify a previously unrecognised strong association between the rs78378222[C] SNP in the 3' untranslated region 3'-UTR of TP53 and both increased risk for developing non-melanomatous skin cancer OR=1.36 95% 1.31 to 1.41, adjusted p=7.62E<sup>-63</sup>, brain malignancy OR=3.12 2.22 to 4.37, adjusted p=1.43E<sup>-12</sup> and increased standing height adjusted p=2.18E<sup>-24</sup>, beta=0.073±0.007, lean body mass adjusted p=8.34E<sup>-37</sup>, beta=0.073±0.005 and basal metabolic rate adjusted p=1.13E<sup>-31</sup>, beta=0.076±0.006, thus offering a novel genetic link between these anthropometric traits and cancer risk.Our results clearly demonstrate that heritable variants in key cancer genes can associate with both differential cancer risk and anthropometric traits in the general population, thereby lending support for a genetic basis for linking these human phenotypes.
Heritable genetic variants in key cancer genes link cancer risk with anthropometric traits.
2020-06-26
1.43
10
Of particular interest, we identify a previously unrecognised strong association between the rs78378222[C] SNP in the 3' untranslated region 3'-UTR of TP53 and both increased risk for developing non-melanomatous skin cancer OR=1.36 95% 1.31 to 1.41, adjusted p=7.62E<sup>-63</sup>, brain malignancy OR=3.12 2.22 to 4.37, adjusted p=1.43E<sup>-12</sup> and increased standing height adjusted p=2.18E<sup>-24</sup>, beta=0.073±0.007, lean body mass adjusted p=8.34E<sup>-37</sup>, beta=0.073±0.005 and basal metabolic rate adjusted p=1.13E<sup>-31</sup>, beta=0.076±0.006, thus offering a novel genetic link between these anthropometric traits and cancer risk.Our results clearly demonstrate that heritable variants in key cancer genes can associate with both differential cancer risk and anthropometric traits in the general population, thereby lending support for a genetic basis for linking these human phenotypes.
Heritable genetic variants in key cancer genes link cancer risk with anthropometric traits.
2020-06-26
-12.0
10
Of particular interest, we identify a previously unrecognised strong association between the rs78378222[C] SNP in the 3' untranslated region 3'-UTR of TP53 and both increased risk for developing non-melanomatous skin cancer OR=1.36 95% 1.31 to 1.41, adjusted p=7.62E<sup>-63</sup>, brain malignancy OR=3.12 2.22 to 4.37, adjusted p=1.43E<sup>-12</sup> and increased standing height adjusted p=2.18E<sup>-24</sup>, beta=0.073±0.007, lean body mass adjusted p=8.34E<sup>-37</sup>, beta=0.073±0.005 and basal metabolic rate adjusted p=1.13E<sup>-31</sup>, beta=0.076±0.006, thus offering a novel genetic link between these anthropometric traits and cancer risk.Our results clearly demonstrate that heritable variants in key cancer genes can associate with both differential cancer risk and anthropometric traits in the general population, thereby lending support for a genetic basis for linking these human phenotypes.
Heritable genetic variants in key cancer genes link cancer risk with anthropometric traits.
2020-06-26
2.18
10
Of particular interest, we identify a previously unrecognised strong association between the rs78378222[C] SNP in the 3' untranslated region 3'-UTR of TP53 and both increased risk for developing non-melanomatous skin cancer OR=1.36 95% 1.31 to 1.41, adjusted p=7.62E<sup>-63</sup>, brain malignancy OR=3.12 2.22 to 4.37, adjusted p=1.43E<sup>-12</sup> and increased standing height adjusted p=2.18E<sup>-24</sup>, beta=0.073±0.007, lean body mass adjusted p=8.34E<sup>-37</sup>, beta=0.073±0.005 and basal metabolic rate adjusted p=1.13E<sup>-31</sup>, beta=0.076±0.006, thus offering a novel genetic link between these anthropometric traits and cancer risk.Our results clearly demonstrate that heritable variants in key cancer genes can associate with both differential cancer risk and anthropometric traits in the general population, thereby lending support for a genetic basis for linking these human phenotypes.
Heritable genetic variants in key cancer genes link cancer risk with anthropometric traits.
2020-06-26
-24.0
10
Of particular interest, we identify a previously unrecognised strong association between the rs78378222[C] SNP in the 3' untranslated region 3'-UTR of TP53 and both increased risk for developing non-melanomatous skin cancer OR=1.36 95% 1.31 to 1.41, adjusted p=7.62E<sup>-63</sup>, brain malignancy OR=3.12 2.22 to 4.37, adjusted p=1.43E<sup>-12</sup> and increased standing height adjusted p=2.18E<sup>-24</sup>, beta=0.073±0.007, lean body mass adjusted p=8.34E<sup>-37</sup>, beta=0.073±0.005 and basal metabolic rate adjusted p=1.13E<sup>-31</sup>, beta=0.076±0.006, thus offering a novel genetic link between these anthropometric traits and cancer risk.Our results clearly demonstrate that heritable variants in key cancer genes can associate with both differential cancer risk and anthropometric traits in the general population, thereby lending support for a genetic basis for linking these human phenotypes.
Heritable genetic variants in key cancer genes link cancer risk with anthropometric traits.
2020-06-26
8.34
10
Of particular interest, we identify a previously unrecognised strong association between the rs78378222[C] SNP in the 3' untranslated region 3'-UTR of TP53 and both increased risk for developing non-melanomatous skin cancer OR=1.36 95% 1.31 to 1.41, adjusted p=7.62E<sup>-63</sup>, brain malignancy OR=3.12 2.22 to 4.37, adjusted p=1.43E<sup>-12</sup> and increased standing height adjusted p=2.18E<sup>-24</sup>, beta=0.073±0.007, lean body mass adjusted p=8.34E<sup>-37</sup>, beta=0.073±0.005 and basal metabolic rate adjusted p=1.13E<sup>-31</sup>, beta=0.076±0.006, thus offering a novel genetic link between these anthropometric traits and cancer risk.Our results clearly demonstrate that heritable variants in key cancer genes can associate with both differential cancer risk and anthropometric traits in the general population, thereby lending support for a genetic basis for linking these human phenotypes.
Heritable genetic variants in key cancer genes link cancer risk with anthropometric traits.
2020-06-26
-37.0
10
Of particular interest, we identify a previously unrecognised strong association between the rs78378222[C] SNP in the 3' untranslated region 3'-UTR of TP53 and both increased risk for developing non-melanomatous skin cancer OR=1.36 95% 1.31 to 1.41, adjusted p=7.62E<sup>-63</sup>, brain malignancy OR=3.12 2.22 to 4.37, adjusted p=1.43E<sup>-12</sup> and increased standing height adjusted p=2.18E<sup>-24</sup>, beta=0.073±0.007, lean body mass adjusted p=8.34E<sup>-37</sup>, beta=0.073±0.005 and basal metabolic rate adjusted p=1.13E<sup>-31</sup>, beta=0.076±0.006, thus offering a novel genetic link between these anthropometric traits and cancer risk.Our results clearly demonstrate that heritable variants in key cancer genes can associate with both differential cancer risk and anthropometric traits in the general population, thereby lending support for a genetic basis for linking these human phenotypes.
Heritable genetic variants in key cancer genes link cancer risk with anthropometric traits.
2020-06-26
1.13
10
Of particular interest, we identify a previously unrecognised strong association between the rs78378222[C] SNP in the 3' untranslated region 3'-UTR of TP53 and both increased risk for developing non-melanomatous skin cancer OR=1.36 95% 1.31 to 1.41, adjusted p=7.62E<sup>-63</sup>, brain malignancy OR=3.12 2.22 to 4.37, adjusted p=1.43E<sup>-12</sup> and increased standing height adjusted p=2.18E<sup>-24</sup>, beta=0.073±0.007, lean body mass adjusted p=8.34E<sup>-37</sup>, beta=0.073±0.005 and basal metabolic rate adjusted p=1.13E<sup>-31</sup>, beta=0.076±0.006, thus offering a novel genetic link between these anthropometric traits and cancer risk.Our results clearly demonstrate that heritable variants in key cancer genes can associate with both differential cancer risk and anthropometric traits in the general population, thereby lending support for a genetic basis for linking these human phenotypes.
Heritable genetic variants in key cancer genes link cancer risk with anthropometric traits.
2020-06-26
-31.0
10
Of particular interest, we identify a previously unrecognised strong association between the rs78378222[C] SNP in the 3' untranslated region 3'-UTR of TP53 and both increased risk for developing non-melanomatous skin cancer OR=1.36 95% 1.31 to 1.41, adjusted p=7.62E<sup>-63</sup>, brain malignancy OR=3.12 2.22 to 4.37, adjusted p=1.43E<sup>-12</sup> and increased standing height adjusted p=2.18E<sup>-24</sup>, beta=0.073±0.007, lean body mass adjusted p=8.34E<sup>-37</sup>, beta=0.073±0.005 and basal metabolic rate adjusted p=1.13E<sup>-31</sup>, beta=0.076±0.006, thus offering a novel genetic link between these anthropometric traits and cancer risk.Our results clearly demonstrate that heritable variants in key cancer genes can associate with both differential cancer risk and anthropometric traits in the general population, thereby lending support for a genetic basis for linking these human phenotypes.
Human H1 receptor (HRH1) gene polymorphism is associated with the severity of side effects after desloratadine treatment in Chinese patients with chronic spontaneous uticaria.
2019-08-13
0.0009
4
The frequency of HRH1 rs901865 G allele was significantly higher in patients who experienced sedation than in patients with rs901865 A allele p = 0.0009.
Human H1 receptor (HRH1) gene polymorphism is associated with the severity of side effects after desloratadine treatment in Chinese patients with chronic spontaneous uticaria.
2019-08-13
0.0009
4
The frequency of HRH1 rs901865 G allele was significantly higher in patients who experienced sedation than in patients with rs901865 A allele p = 0.0009.
Human H1 receptor (HRH1) gene polymorphism is associated with the severity of side effects after desloratadine treatment in Chinese patients with chronic spontaneous uticaria.
2019-08-13
0.005
4
Moreover, patients with the rs901865 G/G genotype suffered a more serious sedation side effect than patients with the rs901865 G/A genotype p = 0.005.
Human H1 receptor (HRH1) gene polymorphism is associated with the severity of side effects after desloratadine treatment in Chinese patients with chronic spontaneous uticaria.
2019-08-13
0.005
4
Moreover, patients with the rs901865 G/G genotype suffered a more serious sedation side effect than patients with the rs901865 G/A genotype p = 0.005.
Melanoma susceptibility variant rs869330 in the MTAP gene is associated with melanoma outcome.
0.048
2
We identified significant associations for rs869330 in the methylthioadenosine phosphorylase - MTAP gene with overall survival hazard ratio = 0.760, P = 0.048, 95% confidence interval: 0.580-0.998 and relapse-free survival hazard ratio = 0.800, P = 0.020, 95% confidence interval: 0.650-0.970.
Melanoma susceptibility variant rs869330 in the MTAP gene is associated with melanoma outcome.
0.02
2
We identified significant associations for rs869330 in the methylthioadenosine phosphorylase - MTAP gene with overall survival hazard ratio = 0.760, P = 0.048, 95% confidence interval: 0.580-0.998 and relapse-free survival hazard ratio = 0.800, P = 0.020, 95% confidence interval: 0.650-0.970.
C-reactive protein (CRP) rs3093059C predicts poor mizolastine response in chronic spontaneous urticaria patients with elevated serum CRP level.
2019-02-11
0.015
4.20
1
Forty 62.50% CSU patients were effective when treated with mizolastine, and 55 72.4% patients were effective in the desloratadine group We found that the patients carried with rs3093059TT genotype were significantly associated with good response OR = 4.20, P = 0.015, had lower serum CRP, IL-6 and TNF-α levels than the CT/CC genotypes.
[Association of CACNA1C gene genetic polymorphism with the susceptibility as well as prognosis for chronic spontaneous urticaria].
0.454
0.843
2
Meanwhile there was no significant difference in general curative effect of the 3 drugs in the 3 SNPs rs58619945: OR=0.843, P=0.454; rs7316246: OR=2.103, P=0.102; rs216008: OR=0.237, P=0.363.
[Association of CACNA1C gene genetic polymorphism with the susceptibility as well as prognosis for chronic spontaneous urticaria].
0.102
2.103
1
Meanwhile there was no significant difference in general curative effect of the 3 drugs in the 3 SNPs rs58619945: OR=0.843, P=0.454; rs7316246: OR=2.103, P=0.102; rs216008: OR=0.237, P=0.363.
[Association of CACNA1C gene genetic polymorphism with the susceptibility as well as prognosis for chronic spontaneous urticaria].
0.363
0.237
2
Meanwhile there was no significant difference in general curative effect of the 3 drugs in the 3 SNPs rs58619945: OR=0.843, P=0.454; rs7316246: OR=2.103, P=0.102; rs216008: OR=0.237, P=0.363.
Genetic variants associated with skin photosensitivity in a southern European population from Spain.
2018-07-25
4.54
5
A standardised questionnaire was used to collect demographic characteristics, pigmentation and sun sensitivity traits, as well as sun exposure habits.MC1R R alleles and IRF4 rs12203592 were significantly associated with sunlight sensitivity at the Bonferroni-corrected level P-value < 4.54 × 10<sup>-3</sup> .
Genetic variants associated with skin photosensitivity in a southern European population from Spain.
2018-07-25
-3.0
5
A standardised questionnaire was used to collect demographic characteristics, pigmentation and sun sensitivity traits, as well as sun exposure habits.MC1R R alleles and IRF4 rs12203592 were significantly associated with sunlight sensitivity at the Bonferroni-corrected level P-value < 4.54 × 10<sup>-3</sup> .
Genetic variants in the HLA class II region associated with risk of cutaneous squamous cell carcinoma.
2018-05-12
9.88
1.20
4
Logistic regression models were used to examine associations between cSCC risk and genotyped or imputed SNPs, classical HLA alleles, and amino acid changes.Among the genotyped SNPs, cSCC risk was associated with rs28535317 OR = 1.20, p = 9.88 × 10<sup>- 11</sup> corresponding to an amino-acid change from phenylalanine to leucine at codon 26 of HLA-DRB1 OR = 1.17, p = 2.48 × 10<sup>- 10</sup>.
Genetic variants in the HLA class II region associated with risk of cutaneous squamous cell carcinoma.
2018-05-12
-11.0
1.17
4
Logistic regression models were used to examine associations between cSCC risk and genotyped or imputed SNPs, classical HLA alleles, and amino acid changes.Among the genotyped SNPs, cSCC risk was associated with rs28535317 OR = 1.20, p = 9.88 × 10<sup>- 11</sup> corresponding to an amino-acid change from phenylalanine to leucine at codon 26 of HLA-DRB1 OR = 1.17, p = 2.48 × 10<sup>- 10</sup>.
Genetic variants in the HLA class II region associated with risk of cutaneous squamous cell carcinoma.
2018-05-12
2.48
4
Logistic regression models were used to examine associations between cSCC risk and genotyped or imputed SNPs, classical HLA alleles, and amino acid changes.Among the genotyped SNPs, cSCC risk was associated with rs28535317 OR = 1.20, p = 9.88 × 10<sup>- 11</sup> corresponding to an amino-acid change from phenylalanine to leucine at codon 26 of HLA-DRB1 OR = 1.17, p = 2.48 × 10<sup>- 10</sup>.
Genetic variants in the HLA class II region associated with risk of cutaneous squamous cell carcinoma.
2018-05-12
-10.0
4
Logistic regression models were used to examine associations between cSCC risk and genotyped or imputed SNPs, classical HLA alleles, and amino acid changes.Among the genotyped SNPs, cSCC risk was associated with rs28535317 OR = 1.20, p = 9.88 × 10<sup>- 11</sup> corresponding to an amino-acid change from phenylalanine to leucine at codon 26 of HLA-DRB1 OR = 1.17, p = 2.48 × 10<sup>- 10</sup>.
Genome-Wide Association Shows that Pigmentation Genes Play a Role in Skin Aging.
2017-05-11
4.1
2
We identified that rs185146 near SLC45A2 is associated with a skin aging trait at genome-wide significance P = 4.1 × 10<sup>-9</sup>; to our knowledge this is previously unreported.
Genome-Wide Association Shows that Pigmentation Genes Play a Role in Skin Aging.
2017-05-11
-9.0
2
We identified that rs185146 near SLC45A2 is associated with a skin aging trait at genome-wide significance P = 4.1 × 10<sup>-9</sup>; to our knowledge this is previously unreported.
Genetic Variants in WNT2B and BTRC Predict Melanoma Survival.
2017-05-10
8.1
1
By performing functional prediction and stepwise selection, we identified two independent SNPs i.e., WNT2B rs1175649 G>T and BTRC rs61873997 G>A that showed a predictive role in CM-specific survival, with an effect-allele-attributed hazards ratio adjusted hazards ratio of 1.99 95% confidence interval = 1.41-2.81, P = 8.10 × 10<sup>-5</sup> and 0.61 0.46-0.80, 3.12×10<sup>-4</sup>, respectively.
Genetic Variants in WNT2B and BTRC Predict Melanoma Survival.
2017-05-10
-5.0
1
By performing functional prediction and stepwise selection, we identified two independent SNPs i.e., WNT2B rs1175649 G>T and BTRC rs61873997 G>A that showed a predictive role in CM-specific survival, with an effect-allele-attributed hazards ratio adjusted hazards ratio of 1.99 95% confidence interval = 1.41-2.81, P = 8.10 × 10<sup>-5</sup> and 0.61 0.46-0.80, 3.12×10<sup>-4</sup>, respectively.
Bayesian logistic regression in detection of gene-steroid interaction for cancer at PDLIM5 locus.
0.00684
2
Single marker analysis using PLINK identified 12 SNPs associated with cancer P< 0.05; especially, SNP rs6532496 revealed the strongest association with cancer P = 6.84 × 10⁻³; while the next best signal was rs951613 P = 7.46 × 10⁻³.
Bayesian logistic regression in detection of gene-steroid interaction for cancer at PDLIM5 locus.
0.00746
2
Single marker analysis using PLINK identified 12 SNPs associated with cancer P< 0.05; especially, SNP rs6532496 revealed the strongest association with cancer P = 6.84 × 10⁻³; while the next best signal was rs951613 P = 7.46 × 10⁻³.
Bayesian logistic regression in detection of gene-steroid interaction for cancer at PDLIM5 locus.
0.0029
2.18
2
Classic logistic regression in PROC GENMOD showed that both rs6532496 and rs951613 revealed strong gene-steroid interaction effects OR=2.18, 95% CI=1.31-3.63 with P = 2.9 × 10⁻³ for rs6532496 and OR=2.07, 95% CI=1.24-3.45 with P = 5.43 × 10⁻³ for rs951613, respectively.
Bayesian logistic regression in detection of gene-steroid interaction for cancer at PDLIM5 locus.
0.00543
2.07
2
Classic logistic regression in PROC GENMOD showed that both rs6532496 and rs951613 revealed strong gene-steroid interaction effects OR=2.18, 95% CI=1.31-3.63 with P = 2.9 × 10⁻³ for rs6532496 and OR=2.07, 95% CI=1.24-3.45 with P = 5.43 × 10⁻³ for rs951613, respectively.
Bayesian logistic regression in detection of gene-steroid interaction for cancer at PDLIM5 locus.
0.0004
2.49
1
SNP rs4634230 revealed the strongest gene-steroid interaction effect OR=2.49, 95% CI=1.5-4.13 with P = 4.0 × 10⁻⁴ based on the classic logistic regression and OR=2.59, 95% CI=1.4-3.97 from Bayesian logistic regression; respectively.
Whole-exome sequencing of over 4100 men of African ancestry and prostate cancer risk.
2015-11-24
1.8e-06
0.78
1
We identified 395 220 coding variants down to 0.05% frequency [57% non-synonymous NS, 42% synonymous and 1% gain or loss of stop codon or splice site variant] in 16 751 genes with the strongest associations observed in SPARCL1 on 4q22.1 rs13051, Ala49Asp, OR = 0.78, P = 1.8 × 10-6 and PTPRR on 12q15 rs73341069, Val239Ile, OR = 1.62, P = 2.5 × 10-5.
Whole-exome sequencing of over 4100 men of African ancestry and prostate cancer risk.
2015-11-24
2.5e-05
1.62
1
We identified 395 220 coding variants down to 0.05% frequency [57% non-synonymous NS, 42% synonymous and 1% gain or loss of stop codon or splice site variant] in 16 751 genes with the strongest associations observed in SPARCL1 on 4q22.1 rs13051, Ala49Asp, OR = 0.78, P = 1.8 × 10-6 and PTPRR on 12q15 rs73341069, Val239Ile, OR = 1.62, P = 2.5 × 10-5.
A Genome-Wide Association Study Identifies the Skin Color Genes IRF4, MC1R, ASIP, and BNC2 Influencing Facial Pigmented Spots.
2015-02-23
1.8e-27
5
We identified genome-wide significant association with pigmented spots at three genetic loci: IRF4 rs12203592, P=1.8 × 10-27, MC1R compound heterozygosity score, P=2.3 × 10-24, and RALY/ASIP rs6059655, P=1.9 × 10-9.
A Genome-Wide Association Study Identifies the Skin Color Genes IRF4, MC1R, ASIP, and BNC2 Influencing Facial Pigmented Spots.
2015-02-23
2.3e-24
1
We identified genome-wide significant association with pigmented spots at three genetic loci: IRF4 rs12203592, P=1.8 × 10-27, MC1R compound heterozygosity score, P=2.3 × 10-24, and RALY/ASIP rs6059655, P=1.9 × 10-9.
A systematic investigation of the contribution of genetic variation within the MHC region to HPV seropositivity.
2015-01-23
1e-14
1.51
2
Our study provides evidence that the association noted between rs41270488 and HPV8 seropositivity is driven by two independent variants, namely DQB1*0301 [odds ratio OR = 1.51, 95% confidence interval CI = 1.36-1.68, P = 1.0 × 10-14] and DRB1*1101 OR = 1.89, 95%CI = 1.57-2.28, P = 1.5 × 10-11 within the HLA class II region.
A systematic investigation of the contribution of genetic variation within the MHC region to HPV seropositivity.
2015-01-23
1.5e-11
1.89
2
Our study provides evidence that the association noted between rs41270488 and HPV8 seropositivity is driven by two independent variants, namely DQB1*0301 [odds ratio OR = 1.51, 95% confidence interval CI = 1.36-1.68, P = 1.0 × 10-14] and DRB1*1101 OR = 1.89, 95%CI = 1.57-2.28, P = 1.5 × 10-11 within the HLA class II region.
Genetic variants in fanconi anemia pathway genes BRCA2 and FANCA predict melanoma survival.
2014-09-22
0.01
1
By performing false-positive report probability corrections and stepwise Cox proportional hazards regression analyses, we identified significant associations between CM OS and four putatively functional SNPs: BRCA2 rs10492396 AG vs. GG: adjusted hazard ratio adjHR=1.85, 95% confidence interval CI=1.16-2.95, P=0.010, rs206118 CC vs. TT+TC: adjHR=2.44, 95% CI=1.27-4.67, P=0.007, rs3752447 CC vs. TT+TC: adjHR=2.10, 95% CI=1.38-3.18, P=0.0005, and FANCA rs62068372 TT vs. CC+CT: adjHR=1.85, 95% CI=1.27-2.69, P=0.001.
Genetic variants in fanconi anemia pathway genes BRCA2 and FANCA predict melanoma survival.
2014-09-22
0.007
1
By performing false-positive report probability corrections and stepwise Cox proportional hazards regression analyses, we identified significant associations between CM OS and four putatively functional SNPs: BRCA2 rs10492396 AG vs. GG: adjusted hazard ratio adjHR=1.85, 95% confidence interval CI=1.16-2.95, P=0.010, rs206118 CC vs. TT+TC: adjHR=2.44, 95% CI=1.27-4.67, P=0.007, rs3752447 CC vs. TT+TC: adjHR=2.10, 95% CI=1.38-3.18, P=0.0005, and FANCA rs62068372 TT vs. CC+CT: adjHR=1.85, 95% CI=1.27-2.69, P=0.001.
Genetic variants in fanconi anemia pathway genes BRCA2 and FANCA predict melanoma survival.
2014-09-22
0.0005
1
By performing false-positive report probability corrections and stepwise Cox proportional hazards regression analyses, we identified significant associations between CM OS and four putatively functional SNPs: BRCA2 rs10492396 AG vs. GG: adjusted hazard ratio adjHR=1.85, 95% confidence interval CI=1.16-2.95, P=0.010, rs206118 CC vs. TT+TC: adjHR=2.44, 95% CI=1.27-4.67, P=0.007, rs3752447 CC vs. TT+TC: adjHR=2.10, 95% CI=1.38-3.18, P=0.0005, and FANCA rs62068372 TT vs. CC+CT: adjHR=1.85, 95% CI=1.27-2.69, P=0.001.
Genetic variants in fanconi anemia pathway genes BRCA2 and FANCA predict melanoma survival.
2014-09-22
0.001
1
By performing false-positive report probability corrections and stepwise Cox proportional hazards regression analyses, we identified significant associations between CM OS and four putatively functional SNPs: BRCA2 rs10492396 AG vs. GG: adjusted hazard ratio adjHR=1.85, 95% confidence interval CI=1.16-2.95, P=0.010, rs206118 CC vs. TT+TC: adjHR=2.44, 95% CI=1.27-4.67, P=0.007, rs3752447 CC vs. TT+TC: adjHR=2.10, 95% CI=1.38-3.18, P=0.0005, and FANCA rs62068372 TT vs. CC+CT: adjHR=1.85, 95% CI=1.27-2.69, P=0.001.
Determinants of vitamin D status in Caucasian adults: influence of sun exposure, dietary intake, sociodemographic, lifestyle, anthropometric, and genetic factors.
2014-09-11
0.0001
1
Mutant GC rs4588 and rs7041 single nucleotide polymorphisms were associated with lower and higher 25OHD concentrations, respectively P<0.0001.
Determinants of vitamin D status in Caucasian adults: influence of sun exposure, dietary intake, sociodemographic, lifestyle, anthropometric, and genetic factors.
2014-09-11
0.0001
1
Mutant GC rs4588 and rs7041 single nucleotide polymorphisms were associated with lower and higher 25OHD concentrations, respectively P<0.0001.
Increased risk of developing cutaneous malignant melanoma is associated with variation in pigmentation genes and VDR, and may involve epistatic effects.
1.715
1.787
1
The results obtained for major function MC1R mutations were the most significant [with odds ratio OR=1.787, confidence interval CI=1.320-2.419 and P=1.715-4], followed by TYR rs1393350 with OR=1.569, CI=1.162-2.118, P=0.003, VDR GCCC haplotype in rs2238136-rs4516035-rs7139166-rs11568820 block with OR=5.653, CI=1.794-17.811, P=0.003 and SLC45A2 rs16891982 with OR=0.238, CI=0.057-0.987, P=0.048.
Increased risk of developing cutaneous malignant melanoma is associated with variation in pigmentation genes and VDR, and may involve epistatic effects.
0.003
1.569
1
The results obtained for major function MC1R mutations were the most significant [with odds ratio OR=1.787, confidence interval CI=1.320-2.419 and P=1.715-4], followed by TYR rs1393350 with OR=1.569, CI=1.162-2.118, P=0.003, VDR GCCC haplotype in rs2238136-rs4516035-rs7139166-rs11568820 block with OR=5.653, CI=1.794-17.811, P=0.003 and SLC45A2 rs16891982 with OR=0.238, CI=0.057-0.987, P=0.048.
Increased risk of developing cutaneous malignant melanoma is associated with variation in pigmentation genes and VDR, and may involve epistatic effects.
0.003
5.653
1
The results obtained for major function MC1R mutations were the most significant [with odds ratio OR=1.787, confidence interval CI=1.320-2.419 and P=1.715-4], followed by TYR rs1393350 with OR=1.569, CI=1.162-2.118, P=0.003, VDR GCCC haplotype in rs2238136-rs4516035-rs7139166-rs11568820 block with OR=5.653, CI=1.794-17.811, P=0.003 and SLC45A2 rs16891982 with OR=0.238, CI=0.057-0.987, P=0.048.
Increased risk of developing cutaneous malignant melanoma is associated with variation in pigmentation genes and VDR, and may involve epistatic effects.
0.048
0.238
1
The results obtained for major function MC1R mutations were the most significant [with odds ratio OR=1.787, confidence interval CI=1.320-2.419 and P=1.715-4], followed by TYR rs1393350 with OR=1.569, CI=1.162-2.118, P=0.003, VDR GCCC haplotype in rs2238136-rs4516035-rs7139166-rs11568820 block with OR=5.653, CI=1.794-17.811, P=0.003 and SLC45A2 rs16891982 with OR=0.238, CI=0.057-0.987, P=0.048.
Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.
2013-04-01
2.4e-14
3
As a result, we identified a new region downstream of the EDNRB gene on 13q22 associated with hair color and the strongest association was the single-nucleotide polymorphism SNP rs975739 P = 2.4 × 10-14; P = 5.4 × 10-9 in the discovery set and P = 1.2 × 10-6 in the replication set.
Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.
2013-04-01
5.4e-09
3
As a result, we identified a new region downstream of the EDNRB gene on 13q22 associated with hair color and the strongest association was the single-nucleotide polymorphism SNP rs975739 P = 2.4 × 10-14; P = 5.4 × 10-9 in the discovery set and P = 1.2 × 10-6 in the replication set.
Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.
2013-04-01
1.2e-06
3
As a result, we identified a new region downstream of the EDNRB gene on 13q22 associated with hair color and the strongest association was the single-nucleotide polymorphism SNP rs975739 P = 2.4 × 10-14; P = 5.4 × 10-9 in the discovery set and P = 1.2 × 10-6 in the replication set.
Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.
2013-04-01
7e-08
3
Using blue, intermediate including green and brown eye colors as co-dominant outcomes, we identified the SNP rs3002288 in VASH2 on 1q32.3 associated with brown eye P = 7.0 × 10-8; P = 5.3 × 10-5 in the discovery set and P = 0.02 in the replication set.
Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.
2013-04-01
5.3e-05
3
Using blue, intermediate including green and brown eye colors as co-dominant outcomes, we identified the SNP rs3002288 in VASH2 on 1q32.3 associated with brown eye P = 7.0 × 10-8; P = 5.3 × 10-5 in the discovery set and P = 0.02 in the replication set.
Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.
2013-04-01
0.02
3
Using blue, intermediate including green and brown eye colors as co-dominant outcomes, we identified the SNP rs3002288 in VASH2 on 1q32.3 associated with brown eye P = 7.0 × 10-8; P = 5.3 × 10-5 in the discovery set and P = 0.02 in the replication set.
Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.
2013-04-01
7.2e-14
5
As for the number of NMSCs, we identified two independent SNPs on chr6 and one SNP on chromosome 14: rs12203592 in IRF4 P = 7.2 × 10-14; P = 1.8 × 10-8 in the discovery set and P = 6.7 × 10-7 in the replication set, rs12202284 between IRF4 and EXOC2 P = 5.0 × 10-8; P = 6.6 × 10-7 in the discovery set and P = 3.0 × 10-3 in the replication set and rs8015138 upstream of GNG2 P = 6.6 × 10-8; P = 5.3 × 10-7 in the discovery set and P = 0.01 in the replication set.
Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.
2013-04-01
1.8e-08
1
As for the number of NMSCs, we identified two independent SNPs on chr6 and one SNP on chromosome 14: rs12203592 in IRF4 P = 7.2 × 10-14; P = 1.8 × 10-8 in the discovery set and P = 6.7 × 10-7 in the replication set, rs12202284 between IRF4 and EXOC2 P = 5.0 × 10-8; P = 6.6 × 10-7 in the discovery set and P = 3.0 × 10-3 in the replication set and rs8015138 upstream of GNG2 P = 6.6 × 10-8; P = 5.3 × 10-7 in the discovery set and P = 0.01 in the replication set.
Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.
2013-04-01
6.7e-07
1
As for the number of NMSCs, we identified two independent SNPs on chr6 and one SNP on chromosome 14: rs12203592 in IRF4 P = 7.2 × 10-14; P = 1.8 × 10-8 in the discovery set and P = 6.7 × 10-7 in the replication set, rs12202284 between IRF4 and EXOC2 P = 5.0 × 10-8; P = 6.6 × 10-7 in the discovery set and P = 3.0 × 10-3 in the replication set and rs8015138 upstream of GNG2 P = 6.6 × 10-8; P = 5.3 × 10-7 in the discovery set and P = 0.01 in the replication set.
Polymorphisms of nucleotide excision repair genes predict melanoma survival.
2013-02-14
0.0003
1
Using the Cox proportional hazards model and Kaplan-Meier analysis, we found a predictive role of XPE rs28720291, ERCC5 rs4150314, XPC rs2470458, and ERCC2 rs50871 SNPs in the prognosis of melanoma patients rs28720291: AG vs. GG, adjusted hazard ratio adjHR=11.2, 95% confidence interval CI 3.04-40.9, P=0.0003; rs4150314: AG vs. GG, adjHR=4.76, 95% CI 1.09-20.8, P=0.038; rs2470458: AA vs. AG/GG, adjHR=2.11, 95% CI 1.03-4.33, P=0.040; and rs50871: AA vs. AC/CC adjHR=2.27, 95% CI 1.18-4.35, P=0.015.
Polymorphisms of nucleotide excision repair genes predict melanoma survival.
2013-02-14
0.038
1
Using the Cox proportional hazards model and Kaplan-Meier analysis, we found a predictive role of XPE rs28720291, ERCC5 rs4150314, XPC rs2470458, and ERCC2 rs50871 SNPs in the prognosis of melanoma patients rs28720291: AG vs. GG, adjusted hazard ratio adjHR=11.2, 95% confidence interval CI 3.04-40.9, P=0.0003; rs4150314: AG vs. GG, adjHR=4.76, 95% CI 1.09-20.8, P=0.038; rs2470458: AA vs. AG/GG, adjHR=2.11, 95% CI 1.03-4.33, P=0.040; and rs50871: AA vs. AC/CC adjHR=2.27, 95% CI 1.18-4.35, P=0.015.
Polymorphisms of nucleotide excision repair genes predict melanoma survival.
2013-02-14
0.04
1
Using the Cox proportional hazards model and Kaplan-Meier analysis, we found a predictive role of XPE rs28720291, ERCC5 rs4150314, XPC rs2470458, and ERCC2 rs50871 SNPs in the prognosis of melanoma patients rs28720291: AG vs. GG, adjusted hazard ratio adjHR=11.2, 95% confidence interval CI 3.04-40.9, P=0.0003; rs4150314: AG vs. GG, adjHR=4.76, 95% CI 1.09-20.8, P=0.038; rs2470458: AA vs. AG/GG, adjHR=2.11, 95% CI 1.03-4.33, P=0.040; and rs50871: AA vs. AC/CC adjHR=2.27, 95% CI 1.18-4.35, P=0.015.
Polymorphisms of nucleotide excision repair genes predict melanoma survival.
2013-02-14
0.015
1
Using the Cox proportional hazards model and Kaplan-Meier analysis, we found a predictive role of XPE rs28720291, ERCC5 rs4150314, XPC rs2470458, and ERCC2 rs50871 SNPs in the prognosis of melanoma patients rs28720291: AG vs. GG, adjusted hazard ratio adjHR=11.2, 95% confidence interval CI 3.04-40.9, P=0.0003; rs4150314: AG vs. GG, adjHR=4.76, 95% CI 1.09-20.8, P=0.038; rs2470458: AA vs. AG/GG, adjHR=2.11, 95% CI 1.03-4.33, P=0.040; and rs50871: AA vs. AC/CC adjHR=2.27, 95% CI 1.18-4.35, P=0.015.
Genome-wide association study of HPV seropositivity.
2011-09-06
1.2e-10
1.37
1
Only one association met genome-wide significance criteria, namely that between HPV8 seropositivity and rs9357152 [odds ratio OR = 1.37, 95% confidence interval CI = 1.24-1.50 for the minor allele G; P=1.2 × 10-10], a common genetic variant minor allele frequency=0.33 located within the major histocompatibility complex MHC II region at 6p21.32.
Genome-wide association study identifies new prostate cancer susceptibility loci.
2011-07-08
0.02
3
Based on in silico replication of 4679 SNPs Stage 1, P < 0.02 in two published GWAS with 7358 PrCa cases and 6732 controls, we identified a new susceptibility locus associated with overall PrCa risk at 2q37.3 rs2292884, P= 4.3 × 10-8.
Genome-wide association study identifies new prostate cancer susceptibility loci.
2011-07-08
4.3e-08
3
Based on in silico replication of 4679 SNPs Stage 1, P < 0.02 in two published GWAS with 7358 PrCa cases and 6732 controls, we identified a new susceptibility locus associated with overall PrCa risk at 2q37.3 rs2292884, P= 4.3 × 10-8.
Genome-wide association study identifies new prostate cancer susceptibility loci.
2011-07-08
0.72
3
The estimated per-allele odds ratios for these loci 1.14 for rs2292884 and 1.17 for rs902774 did not differ between advanced and non-advanced PrCa case-only test for heterogeneity P= 0.72 and P= 0.61, respectively.
Genome-wide association study identifies new prostate cancer susceptibility loci.
2011-07-08
0.61
2
The estimated per-allele odds ratios for these loci 1.14 for rs2292884 and 1.17 for rs902774 did not differ between advanced and non-advanced PrCa case-only test for heterogeneity P= 0.72 and P= 0.61, respectively.
Genome-wide association study identifies novel alleles associated with risk of cutaneous basal cell carcinoma and squamous cell carcinoma.
2011-06-23
4.3e-17
95
1
A non-synonymous SNP in the MC1R gene rs1805007 encoding Arg151Cys substitution, a previously well-documented pigmentation gene, showed the strongest association with BCC risk in the discovery set rs1805007[T]: OR 95% CI for combined discovery set and replication set [1.55 1.45-1.66; P= 4.3 × 10-17].
Genome-wide association study identifies novel alleles associated with risk of cutaneous basal cell carcinoma and squamous cell carcinoma.
2011-06-23
4.3e-17
1
A non-synonymous SNP in the MC1R gene rs1805007 encoding Arg151Cys substitution, a previously well-documented pigmentation gene, showed the strongest association with BCC risk in the discovery set rs1805007[T]: OR 95% CI for combined discovery set and replication set [1.55 1.45-1.66; P= 4.3 × 10-17].
Genome-wide association study identifies novel alleles associated with risk of cutaneous basal cell carcinoma and squamous cell carcinoma.
2011-06-23
9.9e-10
95
1
We identified that an SNP rs12210050 at 6p25 near the EXOC2 gene was associated with an increased risk of BCC [rs12210050[T]: combined OR 95% CI, 1.24 1.17-1.31; P= 9.9 × 10-10].
Genome-wide association study identifies novel alleles associated with risk of cutaneous basal cell carcinoma and squamous cell carcinoma.
2011-06-23
9.9e-10
2
We identified that an SNP rs12210050 at 6p25 near the EXOC2 gene was associated with an increased risk of BCC [rs12210050[T]: combined OR 95% CI, 1.24 1.17-1.31; P= 9.9 × 10-10].
Genome-wide association study identifies novel alleles associated with risk of cutaneous basal cell carcinoma and squamous cell carcinoma.
2011-06-23
2.9e-08
95
2
In the locus on 13q32 near the UBAC2 gene encoding ubiquitin-associated domain-containing protein 2, we also identified a variant conferring susceptibility to BCC [rs7335046 [G]; combined OR 95% CI, 1.26 1.18-1.34; P= 2.9 × 10-8].
Genome-wide association study identifies novel alleles associated with risk of cutaneous basal cell carcinoma and squamous cell carcinoma.
2011-06-23
7.6e-05
95
2
We found that both variants, rs12210050[T] [OR 95% CI, 1.35 1.16-1.57; P= 7.6 × 10-5] and rs7335046 [G] [OR 95% CI, 1.21 1.02-1.44; P= 0.03], were associated with an increased risk of SCC.
Genome-wide association study identifies novel alleles associated with risk of cutaneous basal cell carcinoma and squamous cell carcinoma.
2011-06-23
0.03
95
2
We found that both variants, rs12210050[T] [OR 95% CI, 1.35 1.16-1.57; P= 7.6 × 10-5] and rs7335046 [G] [OR 95% CI, 1.21 1.02-1.44; P= 0.03], were associated with an increased risk of SCC.
Evidence for an association between prostate cancer and chromosome 8q24 and 10q11 genetic variants in African American men: the Flint Men's Health Study.
2010-08-17
0.05
1
Only a small number of studies have evaluated the association between these genetic variants and prostate cancer in African Americans.We used logistic regression models to assess the association between prostate cancer in African American men and 24 SNPs from regions previously reported to be associated with prostate cancer in men of European descent.We found nominal evidence P < 0.05 for association between prostate cancer and three chromosome 8q24 rs6983561, rs16901979, and rs7000448 and two 10q11 rs7904463 and rs10740051 SNPs.We confirm recent reports that 8q24 variants identified to be associated with prostate cancer in men of European descent are also associated with prostate cancer in African Americans.
Evidence for an association between prostate cancer and chromosome 8q24 and 10q11 genetic variants in African American men: the Flint Men's Health Study.
2010-08-17
0.05
1
Only a small number of studies have evaluated the association between these genetic variants and prostate cancer in African Americans.We used logistic regression models to assess the association between prostate cancer in African American men and 24 SNPs from regions previously reported to be associated with prostate cancer in men of European descent.We found nominal evidence P < 0.05 for association between prostate cancer and three chromosome 8q24 rs6983561, rs16901979, and rs7000448 and two 10q11 rs7904463 and rs10740051 SNPs.We confirm recent reports that 8q24 variants identified to be associated with prostate cancer in men of European descent are also associated with prostate cancer in African Americans.
Evidence for an association between prostate cancer and chromosome 8q24 and 10q11 genetic variants in African American men: the Flint Men's Health Study.
2010-08-17
0.05
1
Only a small number of studies have evaluated the association between these genetic variants and prostate cancer in African Americans.We used logistic regression models to assess the association between prostate cancer in African American men and 24 SNPs from regions previously reported to be associated with prostate cancer in men of European descent.We found nominal evidence P < 0.05 for association between prostate cancer and three chromosome 8q24 rs6983561, rs16901979, and rs7000448 and two 10q11 rs7904463 and rs10740051 SNPs.We confirm recent reports that 8q24 variants identified to be associated with prostate cancer in men of European descent are also associated with prostate cancer in African Americans.
Evidence for an association between prostate cancer and chromosome 8q24 and 10q11 genetic variants in African American men: the Flint Men's Health Study.
2010-08-17
0.05
1
Only a small number of studies have evaluated the association between these genetic variants and prostate cancer in African Americans.We used logistic regression models to assess the association between prostate cancer in African American men and 24 SNPs from regions previously reported to be associated with prostate cancer in men of European descent.We found nominal evidence P < 0.05 for association between prostate cancer and three chromosome 8q24 rs6983561, rs16901979, and rs7000448 and two 10q11 rs7904463 and rs10740051 SNPs.We confirm recent reports that 8q24 variants identified to be associated with prostate cancer in men of European descent are also associated with prostate cancer in African Americans.
Evidence for an association between prostate cancer and chromosome 8q24 and 10q11 genetic variants in African American men: the Flint Men's Health Study.
2010-08-17
0.05
1
Only a small number of studies have evaluated the association between these genetic variants and prostate cancer in African Americans.We used logistic regression models to assess the association between prostate cancer in African American men and 24 SNPs from regions previously reported to be associated with prostate cancer in men of European descent.We found nominal evidence P < 0.05 for association between prostate cancer and three chromosome 8q24 rs6983561, rs16901979, and rs7000448 and two 10q11 rs7904463 and rs10740051 SNPs.We confirm recent reports that 8q24 variants identified to be associated with prostate cancer in men of European descent are also associated with prostate cancer in African Americans.
Genome-wide association study of tanning phenotype in a population of European ancestry.
2009-04-02
1.6e-09
1
An initial analysis of 528,173 single-nucleotide polymorphisms SNPs genotyped on 2,287 women identified LOC401937 rs966321 on chromosome 1 as a novel locus highly associated with tanning ability, and we confirmed this association in 870 women controls from a skin cancer case-control study with joint P-value=1.6 x 10-9.