The single-nucleotide polymorphism rs743572 of CYP17A1 shows significant association with polycystic ovary syndrome: a meta-analysis.
2021-06-23
0.028
1.24
2
Overall, the results showed that the rs743572 T>C mutation was most likely to be associated with PCOS risk under the recessive model, which was further confirmed by heterogeneity analysis and publication bias detection CC versus CT + TT, odds ratio [OR] 1.24, 95% confidence interval [CI] 1.02-1.50, P = 0.028, I² = 35.9%.
The single-nucleotide polymorphism rs743572 of CYP17A1 shows significant association with polycystic ovary syndrome: a meta-analysis.
2021-06-23
0.035
1.45
2
Moreover, subgroup analysis by ethnicity demonstrated that Caucasian but not Asian women carrying the CC genotype of rs743572 had an elevated risk of PCOS CC versus CT + TT, OR 1.45, 95% CI 1.03-2.06, P = 0.035, I² = 15.10%, six studies.
Association Analysis of CYP11A1 Variants with Polycystic Ovary Syndrome: a Case-Control Study from North India.
2021-07-06
1e-12
2
The genetic variants of CYP11A1 rs11632698, rs4077582, and rs4887139 demonstrated significant association with PCOS cases p=1.0E-12, p=3.0E-3, p=1.0E-2, respectively.
Association Analysis of CYP11A1 Variants with Polycystic Ovary Syndrome: a Case-Control Study from North India.
2021-07-06
0.003
3
The genetic variants of CYP11A1 rs11632698, rs4077582, and rs4887139 demonstrated significant association with PCOS cases p=1.0E-12, p=3.0E-3, p=1.0E-2, respectively.
Association Analysis of CYP11A1 Variants with Polycystic Ovary Syndrome: a Case-Control Study from North India.
2021-07-06
0.01
1
The genetic variants of CYP11A1 rs11632698, rs4077582, and rs4887139 demonstrated significant association with PCOS cases p=1.0E-12, p=3.0E-3, p=1.0E-2, respectively.
Association between AKT2 gene polymorphism and polycystic ovary syndrome: a case-control study.
2021-05-28
2.0
1.355
1
The risk effect was also detected in the non-obesity group BMI <24.0 kg/m<sup>2</sup> for the Co-dominant model TT vs. TG: OR = 1.355, 95%CI = 1.001-1.835, <i>p</i> = .050.In summary, we first discovered that rs2304186 might significantly elevate the PCOS risk, especially in the Chinese Zhuang population and the non-obesity group Further studies are needed to confirm these results.
Serum spexin, adiponectin and leptin levels in polycystic ovarian syndrome in association with FTO gene polymorphism.
2021-04-29
0.013
3.04
13
The prevalence of A risk allele of SNP rs9939609 was more frequent in PCOS patients than in the control group PCOS risk was found to increase 3 times more in AA genotype when compared with TT genotype OR = 3.04 95% CI: 1.243-7.309; p = 0.013.Serum adiponectin and leptin levels may serve as independent markers for PCOS diagnosis.
Association analysis of KISS1 polymorphisms and haplotypes with polycystic ovary syndrome.
2021-01-22
0.001
4
DNA was extracted, and genotyped for <i>KISS1</i> variants by PCR.rs12998 G > A was linked to PCOS in dominant p < 0.001, recessive p < 0.001, co-dominant p < 0.001, and allelic models p < 0.001.
Association analysis of KISS1 polymorphisms and haplotypes with polycystic ovary syndrome.
2021-01-22
0.001
4
DNA was extracted, and genotyped for <i>KISS1</i> variants by PCR.rs12998 G > A was linked to PCOS in dominant p < 0.001, recessive p < 0.001, co-dominant p < 0.001, and allelic models p < 0.001.
Association analysis of KISS1 polymorphisms and haplotypes with polycystic ovary syndrome.
2021-01-22
0.001
4
DNA was extracted, and genotyped for <i>KISS1</i> variants by PCR.rs12998 G > A was linked to PCOS in dominant p < 0.001, recessive p < 0.001, co-dominant p < 0.001, and allelic models p < 0.001.
Association analysis of KISS1 polymorphisms and haplotypes with polycystic ovary syndrome.
2021-01-22
0.001
4
DNA was extracted, and genotyped for <i>KISS1</i> variants by PCR.rs12998 G > A was linked to PCOS in dominant p < 0.001, recessive p < 0.001, co-dominant p < 0.001, and allelic models p < 0.001.
GALNT2 Gene Variant rs4846914 Is Associated with Insulin and Insulin Resistance Depending on BMI in PCOS Patients: a Case-Control Study.
2020-11-10
0.05
2
In the PCOS group, subjects with genotype AA at the rs4846914 SNP exhibited an increased fasting serum insulin and homeostasis model insulin resistance HOMA-IR index compared with that of corresponding GG or GA genotype carriers all P < 0.05.
GALNT2 Gene Variant rs4846914 Is Associated with Insulin and Insulin Resistance Depending on BMI in PCOS Patients: a Case-Control Study.
2020-11-10
0.05
2
In addition, fasting plasma glucose levels were affected by the genotypes of the rs2144300 SNP in normal control women P < 0.05. rs4846914 and rs2144300 polymorphisms in the GALNT2 gene are associated with insulin and HOMA-IR, BMI, and FSH levels in obese PCOS patients and glucose levels in normal control women, respectively, but not with PCOS.
GALNT2 Gene Variant rs4846914 Is Associated with Insulin and Insulin Resistance Depending on BMI in PCOS Patients: a Case-Control Study.
2020-11-10
0.05
2
In addition, fasting plasma glucose levels were affected by the genotypes of the rs2144300 SNP in normal control women P < 0.05. rs4846914 and rs2144300 polymorphisms in the GALNT2 gene are associated with insulin and HOMA-IR, BMI, and FSH levels in obese PCOS patients and glucose levels in normal control women, respectively, but not with PCOS.
GALNT2 Gene Variant rs4846914 Is Associated with Insulin and Insulin Resistance Depending on BMI in PCOS Patients: a Case-Control Study.
2020-11-10
0.05
2
In addition, fasting plasma glucose levels were affected by the genotypes of the rs2144300 SNP in normal control women P < 0.05. rs4846914 and rs2144300 polymorphisms in the GALNT2 gene are associated with insulin and HOMA-IR, BMI, and FSH levels in obese PCOS patients and glucose levels in normal control women, respectively, but not with PCOS.
Association between human SHBG gene polymorphisms and risk of PCOS: a meta-analysis.
2020-10-14
0.006
1.24
2
The results revealed that SHBG polymorphism of eight or more TAAAAn pentanucleotide repeats rs35785886 was associated with PCOS risk odds ratio [OR] = 1.24, 95% confidence interval [CI] = 1.06, 1.44, Z = 2.77, P = 0.006 and low serum SHBG concentrations in women with PCOS standardized mean difference = -0.83, 95% CI = -1.54, -0.12, Z = 2.30, P = 0.02.
Association between human SHBG gene polymorphisms and risk of PCOS: a meta-analysis.
2020-10-14
0.02
2
The results revealed that SHBG polymorphism of eight or more TAAAAn pentanucleotide repeats rs35785886 was associated with PCOS risk odds ratio [OR] = 1.24, 95% confidence interval [CI] = 1.06, 1.44, Z = 2.77, P = 0.006 and low serum SHBG concentrations in women with PCOS standardized mean difference = -0.83, 95% CI = -1.54, -0.12, Z = 2.30, P = 0.02.
Association between long-chain non-coding RNA SRA1 gene single-nucleotide polymorphism and polycystic ovary syndrome susceptibility.
2020-08-11
0.05
5
To study the association between single-nucleotide polymorphism SNP of long-chain non-coding RNA steroid receptor RNA activator lncRNA SRA1 gene and polycystic ovary syndrome PCOS susceptibility.Sanger sequencing was used to analyze the genotypes of the lncRNA SRA1 gene rs801460, rs10463297, and rs250426 in 315 PCOS patients and 315 control groups.There was no correlation between lncRNA SRA1 gene rs801460, rs250426 SNP, and PCOS susceptibility p > 0.05.
Association between long-chain non-coding RNA SRA1 gene single-nucleotide polymorphism and polycystic ovary syndrome susceptibility.
2020-08-11
0.05
6
To study the association between single-nucleotide polymorphism SNP of long-chain non-coding RNA steroid receptor RNA activator lncRNA SRA1 gene and polycystic ovary syndrome PCOS susceptibility.Sanger sequencing was used to analyze the genotypes of the lncRNA SRA1 gene rs801460, rs10463297, and rs250426 in 315 PCOS patients and 315 control groups.There was no correlation between lncRNA SRA1 gene rs801460, rs250426 SNP, and PCOS susceptibility p > 0.05.
Association between long-chain non-coding RNA SRA1 gene single-nucleotide polymorphism and polycystic ovary syndrome susceptibility.
2020-08-11
0.05
2
To study the association between single-nucleotide polymorphism SNP of long-chain non-coding RNA steroid receptor RNA activator lncRNA SRA1 gene and polycystic ovary syndrome PCOS susceptibility.Sanger sequencing was used to analyze the genotypes of the lncRNA SRA1 gene rs801460, rs10463297, and rs250426 in 315 PCOS patients and 315 control groups.There was no correlation between lncRNA SRA1 gene rs801460, rs250426 SNP, and PCOS susceptibility p > 0.05.
Association between long-chain non-coding RNA SRA1 gene single-nucleotide polymorphism and polycystic ovary syndrome susceptibility.
2020-08-11
0.05
5
To study the association between single-nucleotide polymorphism SNP of long-chain non-coding RNA steroid receptor RNA activator lncRNA SRA1 gene and polycystic ovary syndrome PCOS susceptibility.Sanger sequencing was used to analyze the genotypes of the lncRNA SRA1 gene rs801460, rs10463297, and rs250426 in 315 PCOS patients and 315 control groups.There was no correlation between lncRNA SRA1 gene rs801460, rs250426 SNP, and PCOS susceptibility p > 0.05.
Association between long-chain non-coding RNA SRA1 gene single-nucleotide polymorphism and polycystic ovary syndrome susceptibility.
2020-08-11
0.05
2
To study the association between single-nucleotide polymorphism SNP of long-chain non-coding RNA steroid receptor RNA activator lncRNA SRA1 gene and polycystic ovary syndrome PCOS susceptibility.Sanger sequencing was used to analyze the genotypes of the lncRNA SRA1 gene rs801460, rs10463297, and rs250426 in 315 PCOS patients and 315 control groups.There was no correlation between lncRNA SRA1 gene rs801460, rs250426 SNP, and PCOS susceptibility p > 0.05.
Association between long-chain non-coding RNA SRA1 gene single-nucleotide polymorphism and polycystic ovary syndrome susceptibility.
2020-08-11
2.0
0.54
5
Among people with a BMI ≥ 26.5 kg/m<sup>2</sup>, when carrying the TC genotype and CC genotype at rs801460, the risk of PCOS susceptibility was lower than the TT genotype OR = 0.54, 95%CI: 0.33-0.89, p = 0.02.
Association between long-chain non-coding RNA SRA1 gene single-nucleotide polymorphism and polycystic ovary syndrome susceptibility.
2020-08-11
0.02
5
Among people with a BMI ≥ 26.5 kg/m<sup>2</sup>, when carrying the TC genotype and CC genotype at rs801460, the risk of PCOS susceptibility was lower than the TT genotype OR = 0.54, 95%CI: 0.33-0.89, p = 0.02.
Association between long-chain non-coding RNA SRA1 gene single-nucleotide polymorphism and polycystic ovary syndrome susceptibility.
2020-08-11
0.01
1.66
5
SRA1 gene rs801460, rs10463297, rs250426 constructed TCT haplotype was associated with increased risk of PCOS susceptibility OR = 1.66, 95%CI: 1.20-2.30, p < 0.01; the CTT haplotype was associated with a decreased risk of PCOS susceptibility OR = 0.56, 95%CI: 0.36-0.87, p = 0.01.
Association between long-chain non-coding RNA SRA1 gene single-nucleotide polymorphism and polycystic ovary syndrome susceptibility.
2020-08-11
0.01
0.56
6
SRA1 gene rs801460, rs10463297, rs250426 constructed TCT haplotype was associated with increased risk of PCOS susceptibility OR = 1.66, 95%CI: 1.20-2.30, p < 0.01; the CTT haplotype was associated with a decreased risk of PCOS susceptibility OR = 0.56, 95%CI: 0.36-0.87, p = 0.01.
Association between long-chain non-coding RNA SRA1 gene single-nucleotide polymorphism and polycystic ovary syndrome susceptibility.
2020-08-11
0.01
6
LncRNA SRA1 gene rs10463297 SNP was correlated with the level of lncRNA SRA1 in the peripheral blood leukocytes p < 0.01.From this study, we found that the lncRNA SRA1 gene rs10463297 SNP is associated with PCOS susceptibility.
Association between long-chain non-coding RNA SRA1 gene single-nucleotide polymorphism and polycystic ovary syndrome susceptibility.
2020-08-11
0.01
6
LncRNA SRA1 gene rs10463297 SNP was correlated with the level of lncRNA SRA1 in the peripheral blood leukocytes p < 0.01.From this study, we found that the lncRNA SRA1 gene rs10463297 SNP is associated with PCOS susceptibility.
Verification of a ZBTB16 variant in polycystic ovary syndrome patients.
2020-05-19
1.83
0.556
7
Dominant and additive models were employed for genotype-phenotype association analysis in the PCOS and control samples.The minor allele C of rs1784692 is protective against PCOS odds ratio [OR] 0.556, 95% confidence interval [CI] 0.408-0.759, P = 1.83 × 10<sup>-4</sup>, even after adjustment for body mass index BMI and age OR<sub>adj</sub> 0.539, 95% CI 0.391-0.743, P<sub>adj</sub>= 1.62 × 10<sup>-4</sup>.
Verification of a ZBTB16 variant in polycystic ovary syndrome patients.
2020-05-19
-4.0
7
Dominant and additive models were employed for genotype-phenotype association analysis in the PCOS and control samples.The minor allele C of rs1784692 is protective against PCOS odds ratio [OR] 0.556, 95% confidence interval [CI] 0.408-0.759, P = 1.83 × 10<sup>-4</sup>, even after adjustment for body mass index BMI and age OR<sub>adj</sub> 0.539, 95% CI 0.391-0.743, P<sub>adj</sub>= 1.62 × 10<sup>-4</sup>.
Verification of a ZBTB16 variant in polycystic ovary syndrome patients.
2020-05-19
-4.0
7
Dominant and additive models were employed for genotype-phenotype association analysis in the PCOS and control samples.The minor allele C of rs1784692 is protective against PCOS odds ratio [OR] 0.556, 95% confidence interval [CI] 0.408-0.759, P = 1.83 × 10<sup>-4</sup>, even after adjustment for body mass index BMI and age OR<sub>adj</sub> 0.539, 95% CI 0.391-0.743, P<sub>adj</sub>= 1.62 × 10<sup>-4</sup>.
Verification of a ZBTB16 variant in polycystic ovary syndrome patients.
2020-05-19
1.0
7
Genotype-phenotype analysis of the dominant model showed that mean BMI in the CC+CT group was higher than in the TT group in the PCOS group 27.12 ± 5.82 versus 24.57 ± 4.52, P = 1.0 × 10<sup>-3</sup>, but not in the control groups, indicating that the minor allele C of rs1784692 associates with BMI in women with PCOS.
Verification of a ZBTB16 variant in polycystic ovary syndrome patients.
2020-05-19
-3.0
7
Genotype-phenotype analysis of the dominant model showed that mean BMI in the CC+CT group was higher than in the TT group in the PCOS group 27.12 ± 5.82 versus 24.57 ± 4.52, P = 1.0 × 10<sup>-3</sup>, but not in the control groups, indicating that the minor allele C of rs1784692 associates with BMI in women with PCOS.
Verification of a ZBTB16 variant in polycystic ovary syndrome patients.
2020-05-19
3.06
7
Genotype-phenotype analysis of additive model showed that mean BMI in TC group was higher than in the TT group in PCOS patients compared with control participants 27.14 ± 5.81 versus 24.57 ± 4.52, P = 3.06 × 10<sup>-3</sup>.The SNP rs1784692 in gene ZBTB16 is protective against PCOS but is associated with increased BMI in Han Chinese women with PCOS.
Verification of a ZBTB16 variant in polycystic ovary syndrome patients.
2020-05-19
-3.0
7
Genotype-phenotype analysis of additive model showed that mean BMI in TC group was higher than in the TT group in PCOS patients compared with control participants 27.14 ± 5.81 versus 24.57 ± 4.52, P = 3.06 × 10<sup>-3</sup>.The SNP rs1784692 in gene ZBTB16 is protective against PCOS but is associated with increased BMI in Han Chinese women with PCOS.
Transmission of polycystic ovary syndrome susceptibility single-nucleotide polymorphisms and their association with phenotype changes in offspring.
0.023
2
In male offspring of PCOS mothers, subjects with a T allele at rs2349415 in the gene FSHR had higher FINS P = 0.023, HOMA-IR P = 0.030 and HOMA-β levels P = 0.013 than those in the homozygous CC group The same increased trend in FINS, HOMA-IR and HOMA-β levels could be found in the CC and TC group in rs2268361 located in gene FSHR compared to the TT group P = 0.029, P = 0.030, P = 0.046, respectively.
Transmission of polycystic ovary syndrome susceptibility single-nucleotide polymorphisms and their association with phenotype changes in offspring.
0.03
3
In male offspring of PCOS mothers, subjects with a T allele at rs2349415 in the gene FSHR had higher FINS P = 0.023, HOMA-IR P = 0.030 and HOMA-β levels P = 0.013 than those in the homozygous CC group The same increased trend in FINS, HOMA-IR and HOMA-β levels could be found in the CC and TC group in rs2268361 located in gene FSHR compared to the TT group P = 0.029, P = 0.030, P = 0.046, respectively.
Transmission of polycystic ovary syndrome susceptibility single-nucleotide polymorphisms and their association with phenotype changes in offspring.
0.037
5
As for rs10818854 in the DENND1A gene, the AA and AG group had a higher FINS P = 0.037 and HOMA-β P = 0.008 levels than the homozygous CC groupFirstly, the offspring may be too young to see any phenotype changes.
Transmission of polycystic ovary syndrome susceptibility single-nucleotide polymorphisms and their association with phenotype changes in offspring.
0.008
5
As for rs10818854 in the DENND1A gene, the AA and AG group had a higher FINS P = 0.037 and HOMA-β P = 0.008 levels than the homozygous CC groupFirstly, the offspring may be too young to see any phenotype changes.
Relationship between the characteristic traits of polycystic ovary syndrome and susceptibility genes.
2020-06-26
1.94
6
In women with PCOS, rs11031006, nearest to FSHB, was significantly associated with free testosterone P = 1.94 × 10<sup>-3</sup> and luteinizing hormone P = 1.96 × 10<sup>-3</sup> levels.
Relationship between the characteristic traits of polycystic ovary syndrome and susceptibility genes.
2020-06-26
-3.0
6
In women with PCOS, rs11031006, nearest to FSHB, was significantly associated with free testosterone P = 1.94 × 10<sup>-3</sup> and luteinizing hormone P = 1.96 × 10<sup>-3</sup> levels.
Relationship between the characteristic traits of polycystic ovary syndrome and susceptibility genes.
2020-06-26
1.96
6
In women with PCOS, rs11031006, nearest to FSHB, was significantly associated with free testosterone P = 1.94 × 10<sup>-3</sup> and luteinizing hormone P = 1.96 × 10<sup>-3</sup> levels.
Relationship between the characteristic traits of polycystic ovary syndrome and susceptibility genes.
2020-06-26
-3.0
6
In women with PCOS, rs11031006, nearest to FSHB, was significantly associated with free testosterone P = 1.94 × 10<sup>-3</sup> and luteinizing hormone P = 1.96 × 10<sup>-3</sup> levels.
Association of genetic variations in phosphatase and tensin homolog (PTEN) gene with polycystic ovary syndrome in South Indian women: a case control study.
2020-06-24
0.0016
1
Haplotype frequencies for multiple loci and the standardized disequilibrium coefficient D' for pairwise linkage disequilibrium LD were surveyed by Haploview Software.Our results showed significant increase in the frequencies of rs1903858 A/G P = 0.0016, rs185262832 G/A P = 0.0122 and rs10490920 T/C P = 0.0234 genotypes and alleles in cases compared to controls.The PTEN rs1903858A/G, rs185262832G/A and rs10490920T/C gene polymorphisms may constitute an inheritable risk factor for PCOS in South Indian women.
Association of genetic variations in phosphatase and tensin homolog (PTEN) gene with polycystic ovary syndrome in South Indian women: a case control study.
2020-06-24
0.0122
1
Haplotype frequencies for multiple loci and the standardized disequilibrium coefficient D' for pairwise linkage disequilibrium LD were surveyed by Haploview Software.Our results showed significant increase in the frequencies of rs1903858 A/G P = 0.0016, rs185262832 G/A P = 0.0122 and rs10490920 T/C P = 0.0234 genotypes and alleles in cases compared to controls.The PTEN rs1903858A/G, rs185262832G/A and rs10490920T/C gene polymorphisms may constitute an inheritable risk factor for PCOS in South Indian women.
Association of genetic variations in phosphatase and tensin homolog (PTEN) gene with polycystic ovary syndrome in South Indian women: a case control study.
2020-06-24
0.0234
1
Haplotype frequencies for multiple loci and the standardized disequilibrium coefficient D' for pairwise linkage disequilibrium LD were surveyed by Haploview Software.Our results showed significant increase in the frequencies of rs1903858 A/G P = 0.0016, rs185262832 G/A P = 0.0122 and rs10490920 T/C P = 0.0234 genotypes and alleles in cases compared to controls.The PTEN rs1903858A/G, rs185262832G/A and rs10490920T/C gene polymorphisms may constitute an inheritable risk factor for PCOS in South Indian women.
Association between melatonin receptor gene polymorphisms and polycystic ovarian syndrome: a systematic review and meta-analysis.
0.0
9
In the allelic P=0.000, homozygote P=0.001, dominant P=0.000 and recessive GG vs. GC+CC, P=0.001 model, strong associations between rs10830963 and PCOS were found.
Association between melatonin receptor gene polymorphisms and polycystic ovarian syndrome: a systematic review and meta-analysis.
0.001
9
In the allelic P=0.000, homozygote P=0.001, dominant P=0.000 and recessive GG vs. GC+CC, P=0.001 model, strong associations between rs10830963 and PCOS were found.
Association between melatonin receptor gene polymorphisms and polycystic ovarian syndrome: a systematic review and meta-analysis.
0.0
9
In the allelic P=0.000, homozygote P=0.001, dominant P=0.000 and recessive GG vs. GC+CC, P=0.001 model, strong associations between rs10830963 and PCOS were found.
Association between melatonin receptor gene polymorphisms and polycystic ovarian syndrome: a systematic review and meta-analysis.
0.001
9
In the allelic P=0.000, homozygote P=0.001, dominant P=0.000 and recessive GG vs. GC+CC, P=0.001 model, strong associations between rs10830963 and PCOS were found.
Association between melatonin receptor gene polymorphisms and polycystic ovarian syndrome: a systematic review and meta-analysis.
0.0
5
Moreover, for rs2119882, five genetic models, allelic C vs. T, P=0.000, codominant the homozygote CC vs. TT, P=0.000 and heterozygote model CT vs. TT, P=0.02, dominant CC + CT vs. TT, P=0.03 and recessive model CC vs. CT + TT, P=0.000 showed significant statistical associations with PCOS.MTNR1B rs10830963 and MTNR1B rs2119882 polymorphisms are associated with PCOS risk.
Association between melatonin receptor gene polymorphisms and polycystic ovarian syndrome: a systematic review and meta-analysis.
0.0
9
Moreover, for rs2119882, five genetic models, allelic C vs. T, P=0.000, codominant the homozygote CC vs. TT, P=0.000 and heterozygote model CT vs. TT, P=0.02, dominant CC + CT vs. TT, P=0.03 and recessive model CC vs. CT + TT, P=0.000 showed significant statistical associations with PCOS.MTNR1B rs10830963 and MTNR1B rs2119882 polymorphisms are associated with PCOS risk.
Association between melatonin receptor gene polymorphisms and polycystic ovarian syndrome: a systematic review and meta-analysis.
0.02
5
Moreover, for rs2119882, five genetic models, allelic C vs. T, P=0.000, codominant the homozygote CC vs. TT, P=0.000 and heterozygote model CT vs. TT, P=0.02, dominant CC + CT vs. TT, P=0.03 and recessive model CC vs. CT + TT, P=0.000 showed significant statistical associations with PCOS.MTNR1B rs10830963 and MTNR1B rs2119882 polymorphisms are associated with PCOS risk.
Influence of KISS1 gene polymorphisms on the risk of polycystic ovary syndrome and its associated variables, in Saudi women.
2020-05-07
0.018
4
Among these SNPs, the genotype and allele frequencies of rs372790354 showed significant association with PCOS GA: p = 0.018, AA: p = 0.022, mutant allele-A: p = 0.021 and the G allele was protective.
Influence of KISS1 gene polymorphisms on the risk of polycystic ovary syndrome and its associated variables, in Saudi women.
2020-05-07
0.022
4
Among these SNPs, the genotype and allele frequencies of rs372790354 showed significant association with PCOS GA: p = 0.018, AA: p = 0.022, mutant allele-A: p = 0.021 and the G allele was protective.
Influence of KISS1 gene polymorphisms on the risk of polycystic ovary syndrome and its associated variables, in Saudi women.
2020-05-07
0.021
4
Among these SNPs, the genotype and allele frequencies of rs372790354 showed significant association with PCOS GA: p = 0.018, AA: p = 0.022, mutant allele-A: p = 0.021 and the G allele was protective.
A genome-wide association study of polycystic ovary syndrome identified from electronic health records.
2020-04-11
5.2
1.72
1
In addition, 2 loci with suggestive association were also identified: rs113168128 OR=1.72 [1.42, 2.10], P=5.2×10<sup>-8</sup>, an intronic variant of ERBB4 that is independent from the previously published variants, and rs144248326 OR=2.13 [1.52, 2.86], P=8.45×10<sup>-7</sup>, a novel intronic variant in WWTR1.
A genome-wide association study of polycystic ovary syndrome identified from electronic health records.
2020-04-11
-8.0
2.13
1
In addition, 2 loci with suggestive association were also identified: rs113168128 OR=1.72 [1.42, 2.10], P=5.2×10<sup>-8</sup>, an intronic variant of ERBB4 that is independent from the previously published variants, and rs144248326 OR=2.13 [1.52, 2.86], P=8.45×10<sup>-7</sup>, a novel intronic variant in WWTR1.
A genome-wide association study identifies FSHR rs2300441 associated with follicle-stimulating hormone levels.
2020-03-30
6.7
5
The A allele of rs2300441 led to a reduced level of FSH in the PCOS group β = -.43, P = 6.70 × 10<sup>-14</sup> as well as in the control group β = -.35, P = 6.52 × 10<sup>-4</sup> .
A genome-wide association study identifies FSHR rs2300441 associated with follicle-stimulating hormone levels.
2020-03-30
-14.0
5
The A allele of rs2300441 led to a reduced level of FSH in the PCOS group β = -.43, P = 6.70 × 10<sup>-14</sup> as well as in the control group β = -.35, P = 6.52 × 10<sup>-4</sup> .
A genome-wide association study identifies FSHR rs2300441 associated with follicle-stimulating hormone levels.
2020-03-30
6.52
5
The A allele of rs2300441 led to a reduced level of FSH in the PCOS group β = -.43, P = 6.70 × 10<sup>-14</sup> as well as in the control group β = -.35, P = 6.52 × 10<sup>-4</sup> .
A genome-wide association study identifies FSHR rs2300441 associated with follicle-stimulating hormone levels.
2020-03-30
-4.0
5
The A allele of rs2300441 led to a reduced level of FSH in the PCOS group β = -.43, P = 6.70 × 10<sup>-14</sup> as well as in the control group β = -.35, P = 6.52 × 10<sup>-4</sup> .
A genome-wide association study identifies FSHR rs2300441 associated with follicle-stimulating hormone levels.
2020-03-30
2.0
5
The rs2300441 explained sevenfold higher proportion of the FSH variance than the total variance explained by the two previously reported FSHR missense variants rs2300441 R<sup>2</sup> = 1.40% vs rs6166 R<sup>2</sup> = 0.17%, rs6165 R<sup>2</sup> = 0.03%.
A genome-wide association study identifies FSHR rs2300441 associated with follicle-stimulating hormone levels.
2020-03-30
2.0
2
The rs2300441 explained sevenfold higher proportion of the FSH variance than the total variance explained by the two previously reported FSHR missense variants rs2300441 R<sup>2</sup> = 1.40% vs rs6166 R<sup>2</sup> = 0.17%, rs6165 R<sup>2</sup> = 0.03%.
Association of estrogen receptor gene variants (ESR1 and ESR2) with polycystic ovary syndrome in Tunisia.
2020-03-10
4.81
0.31
1
Logistic regression revealed association of rs2234693, rs3798577 and rs3020314 ESR1 and rs1256049 ESR2, the association of rs2234693 C/T being the strongest with P < 4.81 × 10<sup>-6</sup>, 2.88 × 10<sup>-5</sup> after Bonferroni correction, OR 0.31, 95%CI 0.18-0.53.
Association of estrogen receptor gene variants (ESR1 and ESR2) with polycystic ovary syndrome in Tunisia.
2020-03-10
-6.0
1
Logistic regression revealed association of rs2234693, rs3798577 and rs3020314 ESR1 and rs1256049 ESR2, the association of rs2234693 C/T being the strongest with P < 4.81 × 10<sup>-6</sup>, 2.88 × 10<sup>-5</sup> after Bonferroni correction, OR 0.31, 95%CI 0.18-0.53.
Association of estrogen receptor gene variants (ESR1 and ESR2) with polycystic ovary syndrome in Tunisia.
2020-03-10
-5.0
1
Logistic regression revealed association of rs2234693, rs3798577 and rs3020314 ESR1 and rs1256049 ESR2, the association of rs2234693 C/T being the strongest with P < 4.81 × 10<sup>-6</sup>, 2.88 × 10<sup>-5</sup> after Bonferroni correction, OR 0.31, 95%CI 0.18-0.53.
In depth analysis of the association of FTO SNP (rs9939609) with the expression of classical phenotype of PCOS: a Sri Lankan study.
2020-02-12
0.05
5.7
13
Genetic and clinical data including serum kisspeptin and testosterone concentrations of our previously reported cases n = 55 and controls n = 110 were re-analyzed, specifically for an association with rs9939609 variant of FTO gene.Logistic regression analysis AA - OR = 5.7, 95% CI = 2.41-13.63, p < 0.05 and genetic inheritance analysis AA - OR = 5.49, 95%CI = 2.34-12.88, p < 0.05 showed that FTO rs9939609 polymorphism is significantly associated with PCOS and its metabolic manifestations.
In depth analysis of the association of FTO SNP (rs9939609) with the expression of classical phenotype of PCOS: a Sri Lankan study.
2020-02-12
0.05
5.49
13
Genetic and clinical data including serum kisspeptin and testosterone concentrations of our previously reported cases n = 55 and controls n = 110 were re-analyzed, specifically for an association with rs9939609 variant of FTO gene.Logistic regression analysis AA - OR = 5.7, 95% CI = 2.41-13.63, p < 0.05 and genetic inheritance analysis AA - OR = 5.49, 95%CI = 2.34-12.88, p < 0.05 showed that FTO rs9939609 polymorphism is significantly associated with PCOS and its metabolic manifestations.
In depth analysis of the association of FTO SNP (rs9939609) with the expression of classical phenotype of PCOS: a Sri Lankan study.
2020-02-12
0.05
13
Although serum kisspeptin was higher in subjects with PCOS and mutant alleles than controls, this difference was not significant p > 0.05.FTO gene variant rs9939609 is associated with hyperandrogenemia and metabolic manifestations of PCOS among women of Sri Lankan descent with the well-characterized phenotype.
Association analysis between the tag single nucleotide polymorphisms of DENND1A and the risk of polycystic ovary syndrome in Chinese Han women.
2020-01-15
0.001
1
Significant differences were found in genotypic and allelic distributions at the rs2536951 and rs2479102 loci between PCOS women and controls P < 0.001.
Association analysis between the tag single nucleotide polymorphisms of DENND1A and the risk of polycystic ovary syndrome in Chinese Han women.
2020-01-15
0.001
1
Significant differences were found in genotypic and allelic distributions at the rs2536951 and rs2479102 loci between PCOS women and controls P < 0.001.
Association analysis between the tag single nucleotide polymorphisms of DENND1A and the risk of polycystic ovary syndrome in Chinese Han women.
2020-01-15
0.013
15
The LH levels and LH/FSH ratios were higher in PCOS patients than in the control group A detailed analysis revealed that for the rs2479106 locus, these two values were significantly different in the control subjects who had AA, AG and GG genotypes P = 0.013 and P = 0.007, respectively, and for the rs2468819 locus, these two values were significantly different among the PCOS patients with AA, AG and GG genotypes P = 0.013 and 0.002, respectively.The tagging SNPs rs2479106 and rs2468819 in the DENND1A gene are associated with PCOS in the Chinese population, whereas rs2670139, rs2536951 and rs2479102 are not correlated with PCOS in the same population.
Association analysis between the tag single nucleotide polymorphisms of DENND1A and the risk of polycystic ovary syndrome in Chinese Han women.
2020-01-15
0.007
1
The LH levels and LH/FSH ratios were higher in PCOS patients than in the control group A detailed analysis revealed that for the rs2479106 locus, these two values were significantly different in the control subjects who had AA, AG and GG genotypes P = 0.013 and P = 0.007, respectively, and for the rs2468819 locus, these two values were significantly different among the PCOS patients with AA, AG and GG genotypes P = 0.013 and 0.002, respectively.The tagging SNPs rs2479106 and rs2468819 in the DENND1A gene are associated with PCOS in the Chinese population, whereas rs2670139, rs2536951 and rs2479102 are not correlated with PCOS in the same population.
Association analysis between the tag single nucleotide polymorphisms of DENND1A and the risk of polycystic ovary syndrome in Chinese Han women.
2020-01-15
0.013
15
The LH levels and LH/FSH ratios were higher in PCOS patients than in the control group A detailed analysis revealed that for the rs2479106 locus, these two values were significantly different in the control subjects who had AA, AG and GG genotypes P = 0.013 and P = 0.007, respectively, and for the rs2468819 locus, these two values were significantly different among the PCOS patients with AA, AG and GG genotypes P = 0.013 and 0.002, respectively.The tagging SNPs rs2479106 and rs2468819 in the DENND1A gene are associated with PCOS in the Chinese population, whereas rs2670139, rs2536951 and rs2479102 are not correlated with PCOS in the same population.
MC4R variants rs12970134 and rs17782313 are associated with obese polycystic ovary syndrome patients in the Western region of Saudi Arabia.
2019-08-20
0.05
6
Multinomial logistic regression was used to test the risk of obesity and development of PCOS considering p < 0.05 is statistically significant.Rs12970134 and rs17782313 are significantly associated with body mass index BMI, kg/m<sup>2</sup>, p < 0.0001 in PCOS women but not associated with PCOS itself.
MC4R variants rs12970134 and rs17782313 are associated with obese polycystic ovary syndrome patients in the Western region of Saudi Arabia.
2019-08-20
2.0
6
Multinomial logistic regression was used to test the risk of obesity and development of PCOS considering p < 0.05 is statistically significant.Rs12970134 and rs17782313 are significantly associated with body mass index BMI, kg/m<sup>2</sup>, p < 0.0001 in PCOS women but not associated with PCOS itself.
MC4R variants rs12970134 and rs17782313 are associated with obese polycystic ovary syndrome patients in the Western region of Saudi Arabia.
2019-08-20
0.0001
6
Multinomial logistic regression was used to test the risk of obesity and development of PCOS considering p < 0.05 is statistically significant.Rs12970134 and rs17782313 are significantly associated with body mass index BMI, kg/m<sup>2</sup>, p < 0.0001 in PCOS women but not associated with PCOS itself.
MC4R variants rs12970134 and rs17782313 are associated with obese polycystic ovary syndrome patients in the Western region of Saudi Arabia.
2019-08-20
2.0
1.348
1
Risk alleles in our population are A in rs12970134 and C in rs17782313 that are associated with high BMI > 30 kg/m<sup>2</sup> in obese women with PCOS OR = 1.348, p = 0.002 and OR = 1.364, p = 0.002 respectively in the homozygous state.
MC4R variants rs12970134 and rs17782313 are associated with obese polycystic ovary syndrome patients in the Western region of Saudi Arabia.
2019-08-20
1.364
6
Risk alleles in our population are A in rs12970134 and C in rs17782313 that are associated with high BMI > 30 kg/m<sup>2</sup> in obese women with PCOS OR = 1.348, p = 0.002 and OR = 1.364, p = 0.002 respectively in the homozygous state.
Associations of Leptin Receptor and Peroxisome Proliferator-Activated Receptor Gamma Polymorphisms with Polycystic Ovary Syndrome: A Meta-Analysis.
2019-08-14
0.002
1.88
2
A significant association with susceptibility to PCOS was observed for LEPR rs1137101 polymorphism under recessive genetic model p = 0.002, OR 1.88, 95% CI 1.26-2.78, I2 = 42% and for PPARG rs1801282 polymorphism under dominant p = 0.007, OR 1.20, 95% CI 1.05-1.36, I2 = 49%, overdominant p = 0.02, OR 0.85, 95% CI 0.74-0.97, I2 = 48%, and allele p = 0.006, OR 1.18, 95% CI 1.05-1.33, I2 = 47% genetic models in overall population.
Associations of Leptin Receptor and Peroxisome Proliferator-Activated Receptor Gamma Polymorphisms with Polycystic Ovary Syndrome: A Meta-Analysis.
2019-08-14
0.007
1.20
1
A significant association with susceptibility to PCOS was observed for LEPR rs1137101 polymorphism under recessive genetic model p = 0.002, OR 1.88, 95% CI 1.26-2.78, I2 = 42% and for PPARG rs1801282 polymorphism under dominant p = 0.007, OR 1.20, 95% CI 1.05-1.36, I2 = 49%, overdominant p = 0.02, OR 0.85, 95% CI 0.74-0.97, I2 = 48%, and allele p = 0.006, OR 1.18, 95% CI 1.05-1.33, I2 = 47% genetic models in overall population.
Anti-Müllerian hormone level is associated with vitamin D receptor polymorphisms in women with polycystic ovary syndrome.
2019-05-14
0.05
1
Polymorphisms in VDR gene Fok1 C/T rs2228587, Bsm1 A/G rs1544410, Apa1 A/C rs7975232, and Cdx2 A/G rs11568820 polymorphisms as well as AMH G/T rs10407022 and AMHR2 A/G rs2002555 were analyzed using real-time PCR.Analysis of the VDR Cdx2 polymorphism showed a significantly higher frequency of the homozygous GG mutant genotype in the PCOS group as compared with the control group p < 0.05.
Anti-Müllerian hormone level is associated with vitamin D receptor polymorphisms in women with polycystic ovary syndrome.
2019-05-14
0.05
3
Polymorphisms in VDR gene Fok1 C/T rs2228587, Bsm1 A/G rs1544410, Apa1 A/C rs7975232, and Cdx2 A/G rs11568820 polymorphisms as well as AMH G/T rs10407022 and AMHR2 A/G rs2002555 were analyzed using real-time PCR.Analysis of the VDR Cdx2 polymorphism showed a significantly higher frequency of the homozygous GG mutant genotype in the PCOS group as compared with the control group p < 0.05.
Anti-Müllerian hormone level is associated with vitamin D receptor polymorphisms in women with polycystic ovary syndrome.
2019-05-14
0.05
3
Polymorphisms in VDR gene Fok1 C/T rs2228587, Bsm1 A/G rs1544410, Apa1 A/C rs7975232, and Cdx2 A/G rs11568820 polymorphisms as well as AMH G/T rs10407022 and AMHR2 A/G rs2002555 were analyzed using real-time PCR.Analysis of the VDR Cdx2 polymorphism showed a significantly higher frequency of the homozygous GG mutant genotype in the PCOS group as compared with the control group p < 0.05.
Anti-Müllerian hormone level is associated with vitamin D receptor polymorphisms in women with polycystic ovary syndrome.
2019-05-14
0.05
1
Polymorphisms in VDR gene Fok1 C/T rs2228587, Bsm1 A/G rs1544410, Apa1 A/C rs7975232, and Cdx2 A/G rs11568820 polymorphisms as well as AMH G/T rs10407022 and AMHR2 A/G rs2002555 were analyzed using real-time PCR.Analysis of the VDR Cdx2 polymorphism showed a significantly higher frequency of the homozygous GG mutant genotype in the PCOS group as compared with the control group p < 0.05.
Anti-Müllerian hormone level is associated with vitamin D receptor polymorphisms in women with polycystic ovary syndrome.
2019-05-14
0.05
1
Polymorphisms in VDR gene Fok1 C/T rs2228587, Bsm1 A/G rs1544410, Apa1 A/C rs7975232, and Cdx2 A/G rs11568820 polymorphisms as well as AMH G/T rs10407022 and AMHR2 A/G rs2002555 were analyzed using real-time PCR.Analysis of the VDR Cdx2 polymorphism showed a significantly higher frequency of the homozygous GG mutant genotype in the PCOS group as compared with the control group p < 0.05.
Anti-Müllerian hormone level is associated with vitamin D receptor polymorphisms in women with polycystic ovary syndrome.
2019-05-14
0.05
1
Polymorphisms in VDR gene Fok1 C/T rs2228587, Bsm1 A/G rs1544410, Apa1 A/C rs7975232, and Cdx2 A/G rs11568820 polymorphisms as well as AMH G/T rs10407022 and AMHR2 A/G rs2002555 were analyzed using real-time PCR.Analysis of the VDR Cdx2 polymorphism showed a significantly higher frequency of the homozygous GG mutant genotype in the PCOS group as compared with the control group p < 0.05.
Association of single nucleotide polymorphisms in the <i>RAB5B</i> gene 3'UTR region with polycystic ovary syndrome in Chinese Han women.
2019-05-14
2.0
1
And <i>RAB5B</i> gene rs11550558, rs1045435, and rs11171718 SNPs were significantly associated with PCOS risk only in subjects with BMI ≥ 23.8 kg/m<sup>2</sup> We also found that the <i>RAB5B</i> gene rs1045435 SNP was associated with plasma miR-24 levels.
Association between Interleukin-32 and Interleukin-17A Single Nucleotide Polymorphisms and Serum Levels with Polycystic Ovary Syndrome.
0.005
3
There were significant differences between PCOS and healthy women regarding IL-17A rs2275913 alleles, genotypes frequencies p=0.005, and 0.01, respectively and the allelic distribution of IL-32 rs9927163 SNP p=0.03.
Association between Interleukin-32 and Interleukin-17A Single Nucleotide Polymorphisms and Serum Levels with Polycystic Ovary Syndrome.
0.03
1
There were significant differences between PCOS and healthy women regarding IL-17A rs2275913 alleles, genotypes frequencies p=0.005, and 0.01, respectively and the allelic distribution of IL-32 rs9927163 SNP p=0.03.
Association between Interleukin-32 and Interleukin-17A Single Nucleotide Polymorphisms and Serum Levels with Polycystic Ovary Syndrome.
0.009
3
Additionally, significant differences were indicated between two groups concerning the AG genotype against AA+GG genotypes p=0.009 and the GG genotype against AA+AG genotypes p=0.006 in IL-17A rs2275913 SNP.
Association between Interleukin-32 and Interleukin-17A Single Nucleotide Polymorphisms and Serum Levels with Polycystic Ovary Syndrome.
0.006
3
Additionally, significant differences were indicated between two groups concerning the AG genotype against AA+GG genotypes p=0.009 and the GG genotype against AA+AG genotypes p=0.006 in IL-17A rs2275913 SNP.
Association of vitamin D receptor gene variants with polycystic ovary syndrome: a meta-analysis.
2019-02-14
0.004
1.19
3
A statistically significant association between VDR ApaI rs7975232 polymorphism and PCOS susceptibility C vs. A: OR = 1.19, 95%CI = 1.06~1.34, P = 0.004 was found in the overall population.
Association of vitamin D receptor gene variants with polycystic ovary syndrome: a meta-analysis.
2019-02-14
0.016
1.21
3
After stratified by ethnicity, we showed that there is a significant association between VDR ApaI rs7975232 polymorphism and susceptibility to PCOS in the Asian C vs. A: OR = 1.21, 95%CI = 1.04~1.42, P = 0.016 population, but this association was not found in the Caucasian population.
Association of vitamin D receptor gene variants with polycystic ovary syndrome: a meta-analysis.
2019-02-14
0.011
1.27
3
Additionally, a significant relationship between VDR BsmI rs1544410 variates with PCOS susceptibility in the Asian G vs. A: OR = 1.27, 95%CI = 1.06~1.53, P = 0.011 population, but this association was not found in the Caucasian population.
The influence of the rs1137101 genotypes of leptin receptor gene on the demographic and metabolic profile of normal Saudi females and those suffering from polycystic ovarian syndrome.
2019-01-11
0.009
2
The genotyping of rs1137101 polymorphism in the leptin receptor gene by amplification PCR followed by DNA sequencing, was conducted in both groups PCOS and controls.Waist/hip ratio W/H ratio, leptin serum levels and triglycerides appeared to be associated with PCOS but, aside from W/H ratio AA s GG p = 0.009, this association also occurred for controls.
Identification of selected genetic polymorphisms in polycystic ovary syndrome in Sri Lankan women using low cost genotyping techniques.
2018-12-31
0.05
1
Genotype frequencies of the SNPs GnRH1 rs6185, FSHB rs6169, FSHR rs6165 & rs6166, LHB rs1800447 & rs34349826, LHCGR rs2293275 and INSR rs1799817 were not significantly different between cases and controls p>0.05.
Identification of selected genetic polymorphisms in polycystic ovary syndrome in Sri Lankan women using low cost genotyping techniques.
2018-12-31
0.05
1
Genotype frequencies of the SNPs GnRH1 rs6185, FSHB rs6169, FSHR rs6165 & rs6166, LHB rs1800447 & rs34349826, LHCGR rs2293275 and INSR rs1799817 were not significantly different between cases and controls p>0.05.
Identification of selected genetic polymorphisms in polycystic ovary syndrome in Sri Lankan women using low cost genotyping techniques.
2018-12-31
0.05
1
Genotype frequencies of the SNPs GnRH1 rs6185, FSHB rs6169, FSHR rs6165 & rs6166, LHB rs1800447 & rs34349826, LHCGR rs2293275 and INSR rs1799817 were not significantly different between cases and controls p>0.05.
Identification of selected genetic polymorphisms in polycystic ovary syndrome in Sri Lankan women using low cost genotyping techniques.
2018-12-31
0.05
2
Genotype frequencies of the SNPs GnRH1 rs6185, FSHB rs6169, FSHR rs6165 & rs6166, LHB rs1800447 & rs34349826, LHCGR rs2293275 and INSR rs1799817 were not significantly different between cases and controls p>0.05.
Identification of selected genetic polymorphisms in polycystic ovary syndrome in Sri Lankan women using low cost genotyping techniques.
2018-12-31
0.05
2
Genotype frequencies of the SNPs GnRH1 rs6185, FSHB rs6169, FSHR rs6165 & rs6166, LHB rs1800447 & rs34349826, LHCGR rs2293275 and INSR rs1799817 were not significantly different between cases and controls p>0.05.
Identification of selected genetic polymorphisms in polycystic ovary syndrome in Sri Lankan women using low cost genotyping techniques.
2018-12-31
0.05
2
Genotype frequencies of the SNPs GnRH1 rs6185, FSHB rs6169, FSHR rs6165 & rs6166, LHB rs1800447 & rs34349826, LHCGR rs2293275 and INSR rs1799817 were not significantly different between cases and controls p>0.05.
Identification of selected genetic polymorphisms in polycystic ovary syndrome in Sri Lankan women using low cost genotyping techniques.
2018-12-31
0.05
1
Genotype frequencies of the SNPs GnRH1 rs6185, FSHB rs6169, FSHR rs6165 & rs6166, LHB rs1800447 & rs34349826, LHCGR rs2293275 and INSR rs1799817 were not significantly different between cases and controls p>0.05.
Identification of selected genetic polymorphisms in polycystic ovary syndrome in Sri Lankan women using low cost genotyping techniques.
2018-12-31
0.05
3
Genotype frequencies of the SNPs GnRH1 rs6185, FSHB rs6169, FSHR rs6165 & rs6166, LHB rs1800447 & rs34349826, LHCGR rs2293275 and INSR rs1799817 were not significantly different between cases and controls p>0.05.
Effects of ADIPOQ polymorphisms on PCOS risk: a meta-analysis.
2018-12-03
0.02
0.77
10
Pooled overall analyses showed that rs1501299 polymorphism was significantly associated with PCOS risk recessive model: p = 0.02, OR = 0.77, 95%CI 0.62-0.95; allele model: p = 0.001, OR = 1.15, 95%CI 1.06-1.26.
Effects of ADIPOQ polymorphisms on PCOS risk: a meta-analysis.
2018-12-03
0.001
1.15
10
Pooled overall analyses showed that rs1501299 polymorphism was significantly associated with PCOS risk recessive model: p = 0.02, OR = 0.77, 95%CI 0.62-0.95; allele model: p = 0.001, OR = 1.15, 95%CI 1.06-1.26.
Bidirectional Mendelian randomization to explore the causal relationships between body mass index and polycystic ovary syndrome.
0.0006
2
The association of FTO SNP rs1421085 with BMI was stronger in women with PCOS β = 0.071, P = 0.0006 than in controls β = 0.046, P = 0.065.The current sample size, while providing good power for MR and genetic risk score analyses, had limited power to demonstrate association of individual SNPs with PCOS.
Bidirectional Mendelian randomization to explore the causal relationships between body mass index and polycystic ovary syndrome.
0.065
2
The association of FTO SNP rs1421085 with BMI was stronger in women with PCOS β = 0.071, P = 0.0006 than in controls β = 0.046, P = 0.065.The current sample size, while providing good power for MR and genetic risk score analyses, had limited power to demonstrate association of individual SNPs with PCOS.
Preliminary study showing no association between G238A (rs361525) tumor necrosis factor-α (TNF-α) gene polymorphism and its serum level, hormonal and biochemical aspects of polycystic ovary syndrome.
2018-08-22
0.01
1.98
3
High LH/FSH ratios odds ratio [OR] = 1.98, 95% confidence interval [CI] = 1.20-3.28, p < 0.01, and high HOMA factor OR = 5.04, 95% CI = 2.82-9.01, p < 0.001 were significantly associated with an increased risk of PCOS.Despite the lack of significant difference between rs361525 polymorphism of the TNF-α gene and PCOS, the serum level of TNF-α was increased in PCOS patients and positively correlated with the HOMA factor.
Preliminary study showing no association between G238A (rs361525) tumor necrosis factor-α (TNF-α) gene polymorphism and its serum level, hormonal and biochemical aspects of polycystic ovary syndrome.
2018-08-22
0.001
5.04
3
High LH/FSH ratios odds ratio [OR] = 1.98, 95% confidence interval [CI] = 1.20-3.28, p < 0.01, and high HOMA factor OR = 5.04, 95% CI = 2.82-9.01, p < 0.001 were significantly associated with an increased risk of PCOS.Despite the lack of significant difference between rs361525 polymorphism of the TNF-α gene and PCOS, the serum level of TNF-α was increased in PCOS patients and positively correlated with the HOMA factor.
Effects of apoC1 genotypes on the hormonal levels, metabolic profile and PAF-AH activity in Chinese women with polycystic ovary syndrome.
2018-04-10
0.05
1
The clinical, hormonal and metabolic parameters and PAF-AH activity were measured.The frequencies of apoC1 rs4420638A/G and -317H1/H2 genotypes and alleles were similar between PCOS and control groups P > 0.05.
Effects of apoC1 genotypes on the hormonal levels, metabolic profile and PAF-AH activity in Chinese women with polycystic ovary syndrome.
2018-04-10
0.05
2
However, the rs4420638 G allele was related to increased serum luteinizing hormone, cholesterol and apoB levels, and the ratio of apoB to apoA1 P < 0.05, and the -317H1H1 genotype was associated with a higher acne grade score and a higher ratio of apoB-PAF-AH to H-PAF-AH activity P < 0.05 in patients with PCOS.
Effects of apoC1 genotypes on the hormonal levels, metabolic profile and PAF-AH activity in Chinese women with polycystic ovary syndrome.
2018-04-10
0.05
2
However, the rs4420638 G allele was related to increased serum luteinizing hormone, cholesterol and apoB levels, and the ratio of apoB to apoA1 P < 0.05, and the -317H1H1 genotype was associated with a higher acne grade score and a higher ratio of apoB-PAF-AH to H-PAF-AH activity P < 0.05 in patients with PCOS.
The preliminary association study of ADIPOQ, RBP4, and BCMO1 variants with polycystic ovary syndrome and with biochemical characteristics in a cohort of Polish women.
2018-02-08
0.41
10
Additionally, the relationship of these polymorphisms to a clinical phenotype of this syndrome, and the concentrations of adipokines, were determined.Clinical and biochemical profiles, DNA isolation and genotyping, and adipokine assays were performed in 294 PCOS women and 78 controls.In a cohort of Polish women, for the genotype distribution and allele frequencies minor allele frequency - MAF proved that only the SNP rs1501299 in the gene ADIPOQ P = 0.0010, OR = 0.41, 95% C.I.
The preliminary association study of ADIPOQ, RBP4, and BCMO1 variants with polycystic ovary syndrome and with biochemical characteristics in a cohort of Polish women.
2018-02-08
0.001
10
Additionally, the relationship of these polymorphisms to a clinical phenotype of this syndrome, and the concentrations of adipokines, were determined.Clinical and biochemical profiles, DNA isolation and genotyping, and adipokine assays were performed in 294 PCOS women and 78 controls.In a cohort of Polish women, for the genotype distribution and allele frequencies minor allele frequency - MAF proved that only the SNP rs1501299 in the gene ADIPOQ P = 0.0010, OR = 0.41, 95% C.I.
The preliminary association study of ADIPOQ, RBP4, and BCMO1 variants with polycystic ovary syndrome and with biochemical characteristics in a cohort of Polish women.
2018-02-08
0.0106
0.24
1
:0.24-0.70 and rs7501331 in the gene BCMO1 P = 0.0106, OR = 0.24, 95% C.I.
The preliminary association study of ADIPOQ, RBP4, and BCMO1 variants with polycystic ovary syndrome and with biochemical characteristics in a cohort of Polish women.
2018-02-08
0.034
1
There was a link between rs12934922 of BCMO1 gen and serum concentration of RBP4 P = 0.034 and adiponectin P = 0.038 in the study group but not in the control group The elevated mean serum concentration of cholesterol P = 0.020 and LDL cholesterol P = 0.005 was observed for GG rs1501299 genotype and triglycerides P = 0.028 for TT rs2241766 genotype.The results of the present study revealed that the genes variants RBP4 is not associated with PCO.
The preliminary association study of ADIPOQ, RBP4, and BCMO1 variants with polycystic ovary syndrome and with biochemical characteristics in a cohort of Polish women.
2018-02-08
0.038
10
There was a link between rs12934922 of BCMO1 gen and serum concentration of RBP4 P = 0.034 and adiponectin P = 0.038 in the study group but not in the control group The elevated mean serum concentration of cholesterol P = 0.020 and LDL cholesterol P = 0.005 was observed for GG rs1501299 genotype and triglycerides P = 0.028 for TT rs2241766 genotype.The results of the present study revealed that the genes variants RBP4 is not associated with PCO.
The preliminary association study of ADIPOQ, RBP4, and BCMO1 variants with polycystic ovary syndrome and with biochemical characteristics in a cohort of Polish women.
2018-02-08
0.02
9
There was a link between rs12934922 of BCMO1 gen and serum concentration of RBP4 P = 0.034 and adiponectin P = 0.038 in the study group but not in the control group The elevated mean serum concentration of cholesterol P = 0.020 and LDL cholesterol P = 0.005 was observed for GG rs1501299 genotype and triglycerides P = 0.028 for TT rs2241766 genotype.The results of the present study revealed that the genes variants RBP4 is not associated with PCO.
Association of miR-146a rs2910164 and miR-222 rs2858060 polymorphisms with the risk of polycystic ovary syndrome in Iranian women: A case-control study.
0.001
2.03
1
The association between genotypes and the risk of PCOS was examined by odds ratios OR and 95% of confidence intervals CIs.Our results showed that there are significant differences in CG genotype frequencies between case and control groups regarding miR-146a rs2910164 polymorphism OR = 2.03, CI = 1.3-3, P = 0.001.
A Missense Variant rs4645843 in TNF-α Gene Is a Risk Factor of Polycystic Ovary Syndrome in the Uygur Population.
0.03
2
We thus found that both the genotypic and allelic distributions of rs4645843 were significantly different between PCOS and control groups p = 0.03 and 0.024, respectively, whereas those of rs1800629 were similar between the groups.
A Missense Variant rs4645843 in TNF-α Gene Is a Risk Factor of Polycystic Ovary Syndrome in the Uygur Population.
0.03
4
We thus found that both the genotypic and allelic distributions of rs4645843 were significantly different between PCOS and control groups p = 0.03 and 0.024, respectively, whereas those of rs1800629 were similar between the groups.
Association between fat mass and obesity associated (FTO) gene rs9939609 A/T polymorphism and polycystic ovary syndrome: a systematic review and meta-analysis.
2017-08-21
1e-05
1.41
13
The results of meta-analysis showed that the FTO gene rs9939609 A/T polymorphism was significantly different between PCOS group and control group in different gene models For AA + AT vs. TT: OR = 1.41, 95% CI = 1.28-1.55, P < 0.00001.
Association between fat mass and obesity associated (FTO) gene rs9939609 A/T polymorphism and polycystic ovary syndrome: a systematic review and meta-analysis.
2017-08-21
0.0001
1.43
13
Furthermore, subgroup analysis in Asian and Caucasian ethnicities also found significant association between rs9939609 A/T polymorphism and PCOS In Asian subgroup: OR = 1.43, 95% CI = 1.29-1.59, P < 0.0001.
Association between fat mass and obesity associated (FTO) gene rs9939609 A/T polymorphism and polycystic ovary syndrome: a systematic review and meta-analysis.
2017-08-21
0.008
1.33
13
In Caucasian subgroup: OR = 1.33, 95% CI = 1.08-1.64, P = 0.008 CONCLUSION: This meta-analysis suggests that rs9939609 A/T polymorphism of FTO gene is associated with PCOS risk, and that A allele is a risk factor for PCOS susceptibility simultaneously.
VDR Gene variation and insulin resistance related diseases.
2017-08-19
0.04
1
Simultaneously, sub-group analysis showed VDR ApaI rs7975232G > Tvariant was associated with insulin resistance related diseases in Asians GG/GT + TT OR, 1.62; 95% CI, 1.03-2.53; P = 0.04 and population who lived in middle latitude district 30-60° GG/GT + TT OR, 1.22; 95% CI, 1.04-1.43; P = 0.02, VDR BsmI rs1544410 A > Gand VDR Taq1rs731236 T/C variant were associated with insulin resistance related diseases in Caucasian dark-pigmented.The results suggested that the association between insulin resistance related diseases and VDR ApaI, BsmI, FokI variant was more obvious in dark-pigmented Caucasians and Asians but not in Caucasian with white skin.
VDR Gene variation and insulin resistance related diseases.
2017-08-19
0.02
3
Simultaneously, sub-group analysis showed VDR ApaI rs7975232G > Tvariant was associated with insulin resistance related diseases in Asians GG/GT + TT OR, 1.62; 95% CI, 1.03-2.53; P = 0.04 and population who lived in middle latitude district 30-60° GG/GT + TT OR, 1.22; 95% CI, 1.04-1.43; P = 0.02, VDR BsmI rs1544410 A > Gand VDR Taq1rs731236 T/C variant were associated with insulin resistance related diseases in Caucasian dark-pigmented.The results suggested that the association between insulin resistance related diseases and VDR ApaI, BsmI, FokI variant was more obvious in dark-pigmented Caucasians and Asians but not in Caucasian with white skin.
Association study of HNF1A in women with polycystic ovary syndrome.
2017-03-15
0.023
2
Two single-nucleotide polymorphisms SNPs-rs2393791 and rs7305618-located in HNF1A were genotyped using the Sequenom MassARRAY system.The allele frequencies of SNP rs7305618 had significant differences between PCOS patients and controls after adjusting for age and BMI p = 0.023.
Association study of HNF1A in women with polycystic ovary syndrome.
2017-03-15
0.023
3
Two single-nucleotide polymorphisms SNPs-rs2393791 and rs7305618-located in HNF1A were genotyped using the Sequenom MassARRAY system.The allele frequencies of SNP rs7305618 had significant differences between PCOS patients and controls after adjusting for age and BMI p = 0.023.
Association study of HNF1A in women with polycystic ovary syndrome.
2017-03-15
0.023
3
Two single-nucleotide polymorphisms SNPs-rs2393791 and rs7305618-located in HNF1A were genotyped using the Sequenom MassARRAY system.The allele frequencies of SNP rs7305618 had significant differences between PCOS patients and controls after adjusting for age and BMI p = 0.023.
Association study of HNF1A in women with polycystic ovary syndrome.
2017-03-15
0.019
3
Besides, PCOS patients carrying the rs7305618 CC genotype shown a higher testosterone level than the patients with CT + TT genotypes after being adjusted by age and BMI p = 0.019.A SNP located in the HNF1A gene is associated with PCOS among Han Chinese women.
Genetic variant in vitamin D-binding protein is associated with metabolic syndrome and lower 25-hydroxyvitamin D levels in polycystic ovary syndrome: A cross-sectional study.
2017-03-09
0.027
4
A higher frequency of genotype TT of rs7041 was found in PCOS participants with MetS OR: 2.21, 95%CI:1.08-4.52; p = 0.027.
ERBB4 Confers Risk for Polycystic Ovary Syndrome in Han Chinese.
2017-02-14
0.00105
1
Genotyping analysis showed the allele frequency of rs1351592 in gene ERBB4 was significantly different P = 1.05E-03 between PCOS cases and control group, and remained significant even after BMI adjustment P<sub>adjusted</sub> = 2.09E-04.
Association of VDBP and CYP2R1 gene polymorphisms with vitamin D status in women with polycystic ovarian syndrome: a north Indian study.
2016-12-23
0.008
4
Genotyping of VDBP single nucleotide polymorphisms SNPs rs7041 HaeIII; G>T and rs4588 StyI; A>C and CYP2R1 SNP rs2060793 HinfI; A>G was carried out by restriction fragment length polymorphism in 50 cases of PCOS that were compared with 50 age-matched healthy women.Vitamin D levels were found to be significantly lower in women with PCOS p = 0.008 than in age-matched controls.
Association of VDBP and CYP2R1 gene polymorphisms with vitamin D status in women with polycystic ovarian syndrome: a north Indian study.
2016-12-23
0.008
2
Genotyping of VDBP single nucleotide polymorphisms SNPs rs7041 HaeIII; G>T and rs4588 StyI; A>C and CYP2R1 SNP rs2060793 HinfI; A>G was carried out by restriction fragment length polymorphism in 50 cases of PCOS that were compared with 50 age-matched healthy women.Vitamin D levels were found to be significantly lower in women with PCOS p = 0.008 than in age-matched controls.
Association of VDBP and CYP2R1 gene polymorphisms with vitamin D status in women with polycystic ovarian syndrome: a north Indian study.
2016-12-23
0.008
1
Genotyping of VDBP single nucleotide polymorphisms SNPs rs7041 HaeIII; G>T and rs4588 StyI; A>C and CYP2R1 SNP rs2060793 HinfI; A>G was carried out by restriction fragment length polymorphism in 50 cases of PCOS that were compared with 50 age-matched healthy women.Vitamin D levels were found to be significantly lower in women with PCOS p = 0.008 than in age-matched controls.
Association of VDBP and CYP2R1 gene polymorphisms with vitamin D status in women with polycystic ovarian syndrome: a north Indian study.
2016-12-23
0.04
4
In women with a vitamin D deficiency <20 ng/ml, the GT allele of the VDBP SNP rs7041 p value =0.04, the VDBP allelic combination Gc1F/1F T allele of rs4588 and C allele of rs7041 p value =0.03, and the GA allele of the CYP2R1 SNP rs2060793 p = 0.05 were associated with an increased risk of developing PCOS.The present study shows that the GT allele of VDBP SNP rs7041, the VDBP allelic combination GC1F/1F, and GA allele of CYP2R1 SNP rs2060793 in vitamin D deficient women increase the risk of PCOS.
Association of VDBP and CYP2R1 gene polymorphisms with vitamin D status in women with polycystic ovarian syndrome: a north Indian study.
2016-12-23
0.03
2
In women with a vitamin D deficiency <20 ng/ml, the GT allele of the VDBP SNP rs7041 p value =0.04, the VDBP allelic combination Gc1F/1F T allele of rs4588 and C allele of rs7041 p value =0.03, and the GA allele of the CYP2R1 SNP rs2060793 p = 0.05 were associated with an increased risk of developing PCOS.The present study shows that the GT allele of VDBP SNP rs7041, the VDBP allelic combination GC1F/1F, and GA allele of CYP2R1 SNP rs2060793 in vitamin D deficient women increase the risk of PCOS.
Association of VDBP and CYP2R1 gene polymorphisms with vitamin D status in women with polycystic ovarian syndrome: a north Indian study.
2016-12-23
0.05
4
In women with a vitamin D deficiency <20 ng/ml, the GT allele of the VDBP SNP rs7041 p value =0.04, the VDBP allelic combination Gc1F/1F T allele of rs4588 and C allele of rs7041 p value =0.03, and the GA allele of the CYP2R1 SNP rs2060793 p = 0.05 were associated with an increased risk of developing PCOS.The present study shows that the GT allele of VDBP SNP rs7041, the VDBP allelic combination GC1F/1F, and GA allele of CYP2R1 SNP rs2060793 in vitamin D deficient women increase the risk of PCOS.
Single nucleotide polymorphisms in the TGF-β1 gene are associated with polycystic ovary syndrome susceptibility and characteristics: a study in Korean women.
2016-10-29
0.003
1
We also analyzed laboratory measurements, such as free testosterone, glucose, and cholesterol.The frequencies of rs1800469T allele negativity, rs4803457T allele negativity, the rs1800469CC genotype, and the rs4803457CC genotype showed positive associations with PCOS P = 0.003, P = 0.027, P = 0.009, and P=0.031, respectively, whereas the haplotypes rs1800469C-rs4803457T and rs1800469T-rs4803457T showed negative associations with PCOS.
Single nucleotide polymorphisms in the TGF-β1 gene are associated with polycystic ovary syndrome susceptibility and characteristics: a study in Korean women.
2016-10-29
0.027
1
We also analyzed laboratory measurements, such as free testosterone, glucose, and cholesterol.The frequencies of rs1800469T allele negativity, rs4803457T allele negativity, the rs1800469CC genotype, and the rs4803457CC genotype showed positive associations with PCOS P = 0.003, P = 0.027, P = 0.009, and P=0.031, respectively, whereas the haplotypes rs1800469C-rs4803457T and rs1800469T-rs4803457T showed negative associations with PCOS.
Single nucleotide polymorphisms in the TGF-β1 gene are associated with polycystic ovary syndrome susceptibility and characteristics: a study in Korean women.
2016-10-29
0.009
1
We also analyzed laboratory measurements, such as free testosterone, glucose, and cholesterol.The frequencies of rs1800469T allele negativity, rs4803457T allele negativity, the rs1800469CC genotype, and the rs4803457CC genotype showed positive associations with PCOS P = 0.003, P = 0.027, P = 0.009, and P=0.031, respectively, whereas the haplotypes rs1800469C-rs4803457T and rs1800469T-rs4803457T showed negative associations with PCOS.
Single nucleotide polymorphisms in the TGF-β1 gene are associated with polycystic ovary syndrome susceptibility and characteristics: a study in Korean women.
2016-10-29
0.031
1
We also analyzed laboratory measurements, such as free testosterone, glucose, and cholesterol.The frequencies of rs1800469T allele negativity, rs4803457T allele negativity, the rs1800469CC genotype, and the rs4803457CC genotype showed positive associations with PCOS P = 0.003, P = 0.027, P = 0.009, and P=0.031, respectively, whereas the haplotypes rs1800469C-rs4803457T and rs1800469T-rs4803457T showed negative associations with PCOS.
Vascular endothelial growth factor (VEGFA) gene variation in polycystic ovary syndrome in a Tunisian women population.
2016-10-17
0.03
95
2
We observed the association of the genotype CT of the SNP rs30225039 with PCOS phenotype P = 0.03; OR 95 % CI = 2.05 [1.07-3.90] and a trend for correlation of the pair of haplotypes H2/H2 with prolactin levels in plasma P = 0.077; 193.5 ± 94.3 vs 45.7 ± 7.2.
Vascular endothelial growth factor (VEGFA) gene variation in polycystic ovary syndrome in a Tunisian women population.
2016-10-17
0.077
2
We observed the association of the genotype CT of the SNP rs30225039 with PCOS phenotype P = 0.03; OR 95 % CI = 2.05 [1.07-3.90] and a trend for correlation of the pair of haplotypes H2/H2 with prolactin levels in plasma P = 0.077; 193.5 ± 94.3 vs 45.7 ± 7.2.
Genetic variations in the 3'-untranslated region of SLC18A2 are associated with serum FSH concentration in polycystic ovary syndrome patients and regulate gene expression in vitro.
2016-06-28
0.005
2
The gene expression of SLC18A2 was compared with the NCBI's Gene Expression Omnibus datasets.Two common genetic variants in the 3'-untranslated region rs363282 and rs363238 are associated with serum FSH in the PCOS group P= 0.005 and P= 0.001, respectively, while no associations were found in controls.
Genetic variations in the 3'-untranslated region of SLC18A2 are associated with serum FSH concentration in polycystic ovary syndrome patients and regulate gene expression in vitro.
2016-06-28
0.001
2
The gene expression of SLC18A2 was compared with the NCBI's Gene Expression Omnibus datasets.Two common genetic variants in the 3'-untranslated region rs363282 and rs363238 are associated with serum FSH in the PCOS group P= 0.005 and P= 0.001, respectively, while no associations were found in controls.
Genetic variations in the 3'-untranslated region of SLC18A2 are associated with serum FSH concentration in polycystic ovary syndrome patients and regulate gene expression in vitro.
2016-06-28
0.009
2
Functional studies showed that minor alleles of the two variants rs363282-G and rs363238-A had significantly lower luciferase activities than rs363282-A P= 0.009 and rs363238-C P = 0.009.Results were not validated in another independent cohort, though we provided functional evidence of the two SNPs.
Genetic variations in the 3'-untranslated region of SLC18A2 are associated with serum FSH concentration in polycystic ovary syndrome patients and regulate gene expression in vitro.
2016-06-28
0.009
2
Functional studies showed that minor alleles of the two variants rs363282-G and rs363238-A had significantly lower luciferase activities than rs363282-A P= 0.009 and rs363238-C P = 0.009.Results were not validated in another independent cohort, though we provided functional evidence of the two SNPs.
Association between Common Genetic Variants and Polycystic Ovary Syndrome Risk in a Chinese Han Population.
2016-05-23
0.011
1.42
3
Associations between the gene and the risk of PCOS were tested using various genetic models by Statistical Package for the Social Sciences and Plink.We found that rs705702 in the RAB5B/SUOX was associated with PCOS odds ratio=1.42; 95% confidence interval=1.08-1.87, p=0.011 and increased the PCOS risk.
Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility.
2016-04-28
1.54e-09
6
Two SNPs were identified rs11031006 near FSHB, p = 1.54 × 10-9, and rs17293443 in SMAD3, p = 1.57 × 10-8 and replicated p = 3 × 10-3 and p = 1.44 × 10-4, respectively.
Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility.
2016-04-28
1.57e-08
2
Two SNPs were identified rs11031006 near FSHB, p = 1.54 × 10-9, and rs17293443 in SMAD3, p = 1.57 × 10-8 and replicated p = 3 × 10-3 and p = 1.44 × 10-4, respectively.
Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility.
2016-04-28
0.001
6
Based on ∼90,000 births in Iceland, the risk of a mother delivering twins increased by 18% for each copy of allele rs11031006-G and 9% for rs17293443-C. A higher polygenic risk score PRS for DZ twinning, calculated based on the results of the DZ twinning GWAS, was significantly associated with DZ twinning in Iceland p = 0.001.
Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility.
2016-04-28
0.001
2
Based on ∼90,000 births in Iceland, the risk of a mother delivering twins increased by 18% for each copy of allele rs11031006-G and 9% for rs17293443-C. A higher polygenic risk score PRS for DZ twinning, calculated based on the results of the DZ twinning GWAS, was significantly associated with DZ twinning in Iceland p = 0.001.
Variants in FSHB Are Associated With Polycystic Ovary Syndrome and Luteinizing Hormone Level in Han Chinese Women.
2016-03-03
0.00276
3
Then, the variant rs11031010 was genotyped in an independent cohort and the associations with PCOS, endocrine and metabolic traits were assessed.In the current replication study, rs11031010 was associated with PCOS in Han Chinese women P = 2.76 × 10-3, even after adjustment for age and body mass index.
Variants in FSHB Are Associated With Polycystic Ovary Syndrome and Luteinizing Hormone Level in Han Chinese Women.
2016-03-03
0.00276
3
Then, the variant rs11031010 was genotyped in an independent cohort and the associations with PCOS, endocrine and metabolic traits were assessed.In the current replication study, rs11031010 was associated with PCOS in Han Chinese women P = 2.76 × 10-3, even after adjustment for age and body mass index.
Variants in FSHB Are Associated With Polycystic Ovary Syndrome and Luteinizing Hormone Level in Han Chinese Women.
2016-03-03
4.27e-08
3
Meta-analysis with our previous GWAS data showed that the allele frequency difference of rs11031010 between PCOS and controls reached genome-wide significance P = 4.27 × 10-8.
[Case-control based study between polymorphisms in the adiponectin gene and polycystic ovary syndrome].
0.05
3
Four SNP sites rs17300539, rs12495941, rs2241766 and rs1501299 of ADIPOQ were amplified by PCR and then directly sequenced to screen variants.1 The genotype frequencies of AA of rs17300539 in PCOS was significantly higher than controls [57.5% 119/207 versus 48.4% 93/192, P<0.05].
[Case-control based study between polymorphisms in the adiponectin gene and polycystic ovary syndrome].
0.05
4
Four SNP sites rs17300539, rs12495941, rs2241766 and rs1501299 of ADIPOQ were amplified by PCR and then directly sequenced to screen variants.1 The genotype frequencies of AA of rs17300539 in PCOS was significantly higher than controls [57.5% 119/207 versus 48.4% 93/192, P<0.05].
[Case-control based study between polymorphisms in the adiponectin gene and polycystic ovary syndrome].
0.05
9
Four SNP sites rs17300539, rs12495941, rs2241766 and rs1501299 of ADIPOQ were amplified by PCR and then directly sequenced to screen variants.1 The genotype frequencies of AA of rs17300539 in PCOS was significantly higher than controls [57.5% 119/207 versus 48.4% 93/192, P<0.05].
[Case-control based study between polymorphisms in the adiponectin gene and polycystic ovary syndrome].
0.05
10
Four SNP sites rs17300539, rs12495941, rs2241766 and rs1501299 of ADIPOQ were amplified by PCR and then directly sequenced to screen variants.1 The genotype frequencies of AA of rs17300539 in PCOS was significantly higher than controls [57.5% 119/207 versus 48.4% 93/192, P<0.05].
[Case-control based study between polymorphisms in the adiponectin gene and polycystic ovary syndrome].
0.05
3
Four SNP sites rs17300539, rs12495941, rs2241766 and rs1501299 of ADIPOQ were amplified by PCR and then directly sequenced to screen variants.1 The genotype frequencies of AA of rs17300539 in PCOS was significantly higher than controls [57.5% 119/207 versus 48.4% 93/192, P<0.05].
[Case-control based study between polymorphisms in the adiponectin gene and polycystic ovary syndrome].
0.05
1
2 The allele A of rs17300539 [75.8% 314/414] and allele C frequeneies of rs1501299 [76.3% 316/414] in PCOS were significantly higher than controls [67.7% 260/384, 69.0% 265/384, respectively; all P<0.05].
[Case-control based study between polymorphisms in the adiponectin gene and polycystic ovary syndrome].
0.05
1
2 The allele A of rs17300539 [75.8% 314/414] and allele C frequeneies of rs1501299 [76.3% 316/414] in PCOS were significantly higher than controls [67.7% 260/384, 69.0% 265/384, respectively; all P<0.05].
[Case-control based study between polymorphisms in the adiponectin gene and polycystic ovary syndrome].
0.009
2.670
3
3 Further analysis we found rs17300539 AA genotypes had an increased risk for PCOS compared with GG genotype OR=2.670, P=0.009, rs1501299 CC genotype had an increased risk for PCOS compared with AA genotypes OR=2.756, P=0.012; and the difference remained significantly after adjustment for age, testosterone and body mass index P<0.05.No significant differences were observed in genotype and allele frequencies between PCOS and controls for rs2241766 and rs12495941.
[Case-control based study between polymorphisms in the adiponectin gene and polycystic ovary syndrome].
0.012
2.756
10
3 Further analysis we found rs17300539 AA genotypes had an increased risk for PCOS compared with GG genotype OR=2.670, P=0.009, rs1501299 CC genotype had an increased risk for PCOS compared with AA genotypes OR=2.756, P=0.012; and the difference remained significantly after adjustment for age, testosterone and body mass index P<0.05.No significant differences were observed in genotype and allele frequencies between PCOS and controls for rs2241766 and rs12495941.
[Case-control based study between polymorphisms in the adiponectin gene and polycystic ovary syndrome].
0.05
9
3 Further analysis we found rs17300539 AA genotypes had an increased risk for PCOS compared with GG genotype OR=2.670, P=0.009, rs1501299 CC genotype had an increased risk for PCOS compared with AA genotypes OR=2.756, P=0.012; and the difference remained significantly after adjustment for age, testosterone and body mass index P<0.05.No significant differences were observed in genotype and allele frequencies between PCOS and controls for rs2241766 and rs12495941.
FADS1-FADS2 gene cluster confers risk to polycystic ovary syndrome.
2016-02-16
0.00217
0.85
2
Minor allele frequency allele T of rs174570 was significantly lower in PCOS cases than that in age-matched controls P = 2.17E-03, OR = 0.85, even after adjustment of BMI and age.
Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health.
2016-01-04
6e-16
1.06
4
We conducted a GWAS in 9534 individuals to identify genetic variants associated with length of menstrual cycle.The FSH-lowering T allele of the FSHB promoter polymorphism rs10835638; MAF 0.16 was associated with longer menstrual cycles [0.16 SD c. 1 day per minor allele; 95% confidence interval CI 0.12-0.20; P = 6 × 10-16], later age at menopause 0.13 years per minor allele; 95% CI 0.04-0.22; P = 5.7 × 10-3, greater female nulliparity [odds ratio OR = 1.06; 95% CI 1.02-1.11; P = 4.8 × 10-3] and lower risk of endometriosis OR = 0.79; 95% CI 0.69-0.90; P = 4.1 × 10-4.
Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health.
2016-01-04
0.0057
0.79
4
We conducted a GWAS in 9534 individuals to identify genetic variants associated with length of menstrual cycle.The FSH-lowering T allele of the FSHB promoter polymorphism rs10835638; MAF 0.16 was associated with longer menstrual cycles [0.16 SD c. 1 day per minor allele; 95% confidence interval CI 0.12-0.20; P = 6 × 10-16], later age at menopause 0.13 years per minor allele; 95% CI 0.04-0.22; P = 5.7 × 10-3, greater female nulliparity [odds ratio OR = 1.06; 95% CI 1.02-1.11; P = 4.8 × 10-3] and lower risk of endometriosis OR = 0.79; 95% CI 0.69-0.90; P = 4.1 × 10-4.
Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health.
2016-01-04
0.0048
4
We conducted a GWAS in 9534 individuals to identify genetic variants associated with length of menstrual cycle.The FSH-lowering T allele of the FSHB promoter polymorphism rs10835638; MAF 0.16 was associated with longer menstrual cycles [0.16 SD c. 1 day per minor allele; 95% confidence interval CI 0.12-0.20; P = 6 × 10-16], later age at menopause 0.13 years per minor allele; 95% CI 0.04-0.22; P = 5.7 × 10-3, greater female nulliparity [odds ratio OR = 1.06; 95% CI 1.02-1.11; P = 4.8 × 10-3] and lower risk of endometriosis OR = 0.79; 95% CI 0.69-0.90; P = 4.1 × 10-4.
Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health.
2016-01-04
0.00041
4
We conducted a GWAS in 9534 individuals to identify genetic variants associated with length of menstrual cycle.The FSH-lowering T allele of the FSHB promoter polymorphism rs10835638; MAF 0.16 was associated with longer menstrual cycles [0.16 SD c. 1 day per minor allele; 95% confidence interval CI 0.12-0.20; P = 6 × 10-16], later age at menopause 0.13 years per minor allele; 95% CI 0.04-0.22; P = 5.7 × 10-3, greater female nulliparity [odds ratio OR = 1.06; 95% CI 1.02-1.11; P = 4.8 × 10-3] and lower risk of endometriosis OR = 0.79; 95% CI 0.69-0.90; P = 4.1 × 10-4.
Association of single-nucleotide polymorphisms rs2197076 and rs2241883 of FABP1 gene with polycystic ovary syndrome.
2015-12-09
0.001
1
Allele frequency comparison was performed between the PCOS and control groups, and genotype-phenotype correlation analysis was performed using dominant and recessive models to assess the association of FABP1 and the main features of PCOS.Allele frequency analyses showed a strong association of SNPs rs2197076 and rs2241883 of FABP1 gene with PCOS P < 0.001.
Association of single-nucleotide polymorphisms rs2197076 and rs2241883 of FABP1 gene with polycystic ovary syndrome.
2015-12-09
0.001
1
Allele frequency comparison was performed between the PCOS and control groups, and genotype-phenotype correlation analysis was performed using dominant and recessive models to assess the association of FABP1 and the main features of PCOS.Allele frequency analyses showed a strong association of SNPs rs2197076 and rs2241883 of FABP1 gene with PCOS P < 0.001.
Family association study between melatonin receptor gene polymorphisms and polycystic ovary syndrome in Han Chinese.
2015-10-13
0.0209
5
In total, 135 trios of rs2119882 and 127 trios of rs10830963 were tested.An association was detected between rs2119882 p=0.0209 and PCOS, suggesting that the MTNR gene may indicate increased susceptibility to PCOS in Chinese.
Family association study between melatonin receptor gene polymorphisms and polycystic ovary syndrome in Han Chinese.
2015-10-13
0.0209
9
In total, 135 trios of rs2119882 and 127 trios of rs10830963 were tested.An association was detected between rs2119882 p=0.0209 and PCOS, suggesting that the MTNR gene may indicate increased susceptibility to PCOS in Chinese.
Family association study between melatonin receptor gene polymorphisms and polycystic ovary syndrome in Han Chinese.
2015-10-13
0.0209
5
In total, 135 trios of rs2119882 and 127 trios of rs10830963 were tested.An association was detected between rs2119882 p=0.0209 and PCOS, suggesting that the MTNR gene may indicate increased susceptibility to PCOS in Chinese.
Family association study between melatonin receptor gene polymorphisms and polycystic ovary syndrome in Han Chinese.
2015-10-13
0.018
5
A significant difference in transmission of allele C of rs2119882 was found between obese and non-obese women with PCOS Chi-squared=5.5983, p=0.018.This study may provide a basis for further studies of the MTNR gene in the aetiology of PCOS.
Systematic Evaluation of Genetic Variants for Polycystic Ovary Syndrome in a Chinese Population.
2015-10-16
0.000599
3
Variants of rs3802457 in C9orf3 locus P = 5.99×10-4 and rs13405728 in LHCGR locus P = 3.73×10-4 were significantly associated with PCOS after the strict Bonferroni correction in our data set.
Systematic Evaluation of Genetic Variants for Polycystic Ovary Syndrome in a Chinese Population.
2015-10-16
0.000373
8
Variants of rs3802457 in C9orf3 locus P = 5.99×10-4 and rs13405728 in LHCGR locus P = 3.73×10-4 were significantly associated with PCOS after the strict Bonferroni correction in our data set.
Systematic Evaluation of Genetic Variants for Polycystic Ovary Syndrome in a Chinese Population.
2015-10-16
9.85e-06
0.548
1
The further haplotype analysis indicated that in the block of C9orf3 gene rs4385527 and rs3802457, GA haplotype played a protective role in PCOS 8.7 vs 5.0, P = 9.85×10-6, OR = 0.548, 95%CI = 0.418-0.717, while GG haplotype was found suffering from an extraordinarily increased risk of PCOS 73.6% vs79.2%, P = 3.41×10-5, OR = 1.394, 95%CI = 1.191-1.632.
Systematic Evaluation of Genetic Variants for Polycystic Ovary Syndrome in a Chinese Population.
2015-10-16
3.41e-05
1.394
3
The further haplotype analysis indicated that in the block of C9orf3 gene rs4385527 and rs3802457, GA haplotype played a protective role in PCOS 8.7 vs 5.0, P = 9.85×10-6, OR = 0.548, 95%CI = 0.418-0.717, while GG haplotype was found suffering from an extraordinarily increased risk of PCOS 73.6% vs79.2%, P = 3.41×10-5, OR = 1.394, 95%CI = 1.191-1.632.
Association Analysis between the Polymorphisms of HSD11B1 and H6PD and Risk of Polycystic Ovary Syndrome in Chinese Population.
2015-10-09
0.04
1
Genetic variants of HSD11B1 rs846908 and H6PD rs6688832 and rs17368528 were analyzed by TaqMan method.We found a significantly 0.79-fold lower risk of G allele of rs6688832 in control group compared with the patients with PCOS adjusted OR, 0.79; 95%CI = 0.63-0.99; P = 0.040.
Association Analysis between the Polymorphisms of HSD11B1 and H6PD and Risk of Polycystic Ovary Syndrome in Chinese Population.
2015-10-09
0.04
5
Genetic variants of HSD11B1 rs846908 and H6PD rs6688832 and rs17368528 were analyzed by TaqMan method.We found a significantly 0.79-fold lower risk of G allele of rs6688832 in control group compared with the patients with PCOS adjusted OR, 0.79; 95%CI = 0.63-0.99; P = 0.040.
Association Analysis between the Polymorphisms of HSD11B1 and H6PD and Risk of Polycystic Ovary Syndrome in Chinese Population.
2015-10-09
0.04
1
Genetic variants of HSD11B1 rs846908 and H6PD rs6688832 and rs17368528 were analyzed by TaqMan method.We found a significantly 0.79-fold lower risk of G allele of rs6688832 in control group compared with the patients with PCOS adjusted OR, 0.79; 95%CI = 0.63-0.99; P = 0.040.
Association Analysis between the Polymorphisms of HSD11B1 and H6PD and Risk of Polycystic Ovary Syndrome in Chinese Population.
2015-10-09
0.04
5
Genetic variants of HSD11B1 rs846908 and H6PD rs6688832 and rs17368528 were analyzed by TaqMan method.We found a significantly 0.79-fold lower risk of G allele of rs6688832 in control group compared with the patients with PCOS adjusted OR, 0.79; 95%CI = 0.63-0.99; P = 0.040.
Association Analysis between the Polymorphisms of HSD11B1 and H6PD and Risk of Polycystic Ovary Syndrome in Chinese Population.
2015-10-09
0.037
5
When all subjects were divided into different subgroups according to age and body mass index BMI, we found that the frequency of G allele of rs6688832 was significantly higher in controls than that in PCOS patients in the subgroup of BMI > 23 adjusted OR, 0.70; 95% CI = 0.50-0.98; P = 0.037.Our findings showed a statistical association between H6PD rs6688832 and PCOS risk in Chinese population.
Family-based analysis of eight susceptibility loci in polycystic ovary syndrome.
2015-07-29
0.0001
2
Significant differences in transmission were observed for the SNPs rs2349415 located in the FSHR gene, P = 0.0001 and rs3802457 located in the C9orf3 gene, P = 0.0001, even after correction for multiple testing bias.
Family-based analysis of eight susceptibility loci in polycystic ovary syndrome.
2015-07-29
0.0001
3
Significant differences in transmission were observed for the SNPs rs2349415 located in the FSHR gene, P = 0.0001 and rs3802457 located in the C9orf3 gene, P = 0.0001, even after correction for multiple testing bias.
Dense mapping of the region of insulin gene VNTR in polycystic ovary syndrome in a population of women from Central Europe.
0.049
1
Statistical analysis allowed observation of the association of the SNP rs3842748, through its GC genotype, with obesity in PCOS P = 0.049; OR CI95% 1,59 [1.00-2.51] and in classical PCOS YPCOS P = 0.010, as well as the correlation of the SNP rs689 and the pair of haplotypes h1/h1 with higher levels of testosteronaemia in the PCOS group, although this was at the limit of significance P = 0.054 CONCLUSION: These results are in accordance with some studies in literature and highlight the role of insulin gene VNTR in complex metabolic disorders.
Dense mapping of the region of insulin gene VNTR in polycystic ovary syndrome in a population of women from Central Europe.
0.01
1
Statistical analysis allowed observation of the association of the SNP rs3842748, through its GC genotype, with obesity in PCOS P = 0.049; OR CI95% 1,59 [1.00-2.51] and in classical PCOS YPCOS P = 0.010, as well as the correlation of the SNP rs689 and the pair of haplotypes h1/h1 with higher levels of testosteronaemia in the PCOS group, although this was at the limit of significance P = 0.054 CONCLUSION: These results are in accordance with some studies in literature and highlight the role of insulin gene VNTR in complex metabolic disorders.
Gene variants associated with age at menopause are also associated with polycystic ovary syndrome, gonadotrophins and ovarian volume.
2015-05-20
0.004
3
Allele frequencies for variants previously associated with age at menopause were examined in PCOS cases and controls, along with the relationship to quantitative traits.The variant rs11668344-G was associated with decreased risk of PCOS odds ratio: 0.77 [0.59-0.93]; P = 0.004.
Gene variants associated with age at menopause are also associated with polycystic ovary syndrome, gonadotrophins and ovarian volume.
2015-05-20
5.2e-05
2
There was a strong relationship between the late menopause allele rs12294104-T and increased LH levels β ± SE; 0.26 ± 0.06; P = 5.2 × 10-5 and the LH:FSH ratio 0.28 ± 0.06; P = 2.7 × 10-6.
Gene variants associated with age at menopause are also associated with polycystic ovary syndrome, gonadotrophins and ovarian volume.
2015-05-20
2.7e-06
2
There was a strong relationship between the late menopause allele rs12294104-T and increased LH levels β ± SE; 0.26 ± 0.06; P = 5.2 × 10-5 and the LH:FSH ratio 0.28 ± 0.06; P = 2.7 × 10-6.
Gene variants associated with age at menopause are also associated with polycystic ovary syndrome, gonadotrophins and ovarian volume.
2015-05-20
0.02
3
A genetic risk score calculated from 16 independent variants associated with age at menopause was also associated with PCOS P < 0.02, LH and the LH:FSH ratio both P < 0.05.The variant rs11668344 was not associated with PCOS in the Greek cohort, but results exhibited the same direction of effect as the Boston cohort.
Gene variants associated with age at menopause are also associated with polycystic ovary syndrome, gonadotrophins and ovarian volume.
2015-05-20
0.05
3
A genetic risk score calculated from 16 independent variants associated with age at menopause was also associated with PCOS P < 0.02, LH and the LH:FSH ratio both P < 0.05.The variant rs11668344 was not associated with PCOS in the Greek cohort, but results exhibited the same direction of effect as the Boston cohort.
Genetic variability in GLP-1 receptor is associated with inter-individual differences in weight lowering potential of liraglutide in obese women with PCOS: a pilot study.
2015-05-21
0.025
0.27
1
Carriers of at least one polymorphic rs10305420 allele had poor treatment response compared to carriers of two wild type alleles OR = 0.27, 95% CI = 0.09-0.85, P = 0.025.
Genetic variability in GLP-1 receptor is associated with inter-individual differences in weight lowering potential of liraglutide in obese women with PCOS: a pilot study.
2015-05-21
0.058
3.06
1
Carriers of at least one polymorphic rs6923761 allele tended to have stronger treatment response compared to carriers of two wild type alleles OR = 3.06, 95% CI = 0.96-9.74, P = 0.058.
Association Study between Polycystic Ovarian Syndrome and the Susceptibility Genes Polymorphisms in Hui Chinese Women.
2015-05-15
0.05
8
In contrary, there was no statistical difference between the two groups for SNP rs13429458 and rs2479106 P>0.05.The present study suggested that the SNP rs13405728 in the LHCGR gene was associated with PCOS in Hui ethnic women, and its TT genotype characterized with higher level of TT, TG and LDL.
Association Study between Polycystic Ovarian Syndrome and the Susceptibility Genes Polymorphisms in Hui Chinese Women.
2015-05-15
0.05
15
In contrary, there was no statistical difference between the two groups for SNP rs13429458 and rs2479106 P>0.05.The present study suggested that the SNP rs13405728 in the LHCGR gene was associated with PCOS in Hui ethnic women, and its TT genotype characterized with higher level of TT, TG and LDL.
Association Study between Polycystic Ovarian Syndrome and the Susceptibility Genes Polymorphisms in Hui Chinese Women.
2015-05-15
0.05
8
In contrary, there was no statistical difference between the two groups for SNP rs13429458 and rs2479106 P>0.05.The present study suggested that the SNP rs13405728 in the LHCGR gene was associated with PCOS in Hui ethnic women, and its TT genotype characterized with higher level of TT, TG and LDL.
An association study between USP34 and polycystic ovary syndrome.
2015-05-15
0.006
1.042
1
However, rs17008940 was shown to be slightly associated with BMI in PCOS cases rather than in controls, even after age adjustment TC vs CC P = 0.006, OR = 1.042, 95% CI 1.012-1.073; TT vs CC P = 0.037, OR = 1.050, 95% CI 1.003-1.100.USP34 gene polymorphisms rs17008097 and rs17008940 may not be associated with PCOS in the Han Chinese women.
An association study between USP34 and polycystic ovary syndrome.
2015-05-15
0.037
1.050
1
However, rs17008940 was shown to be slightly associated with BMI in PCOS cases rather than in controls, even after age adjustment TC vs CC P = 0.006, OR = 1.042, 95% CI 1.012-1.073; TT vs CC P = 0.037, OR = 1.050, 95% CI 1.003-1.100.USP34 gene polymorphisms rs17008097 and rs17008940 may not be associated with PCOS in the Han Chinese women.
Han Chinese polycystic ovary syndrome risk variants in women of European ancestry: relationship to FSH levels and glucose tolerance.
2015-04-22
0.002
95
3
Allele frequencies for variants associated with PCOS in Han Chinese women were examined in PCOS cases and controls, along with the relationship to quantitative traits.A variant rs2268361-T in an intron of FSHR was associated with PCOS 0.84 [0.76-0.93], OR [95% CI]; P = 0.002.
Han Chinese polycystic ovary syndrome risk variants in women of European ancestry: relationship to FSH levels and glucose tolerance.
2015-04-22
0.0029
3
A variant rs705702-G near RAB5B and SUOX was associated with insulin -0.16 ± 0.05, P = 0.0029 and glucose levels -0.20 ± 0.05, P = 0.0002 120 min after an oral glucose test.The study was large and contained replication cohorts, but was limited by a small number of controls in the Greek cohort and a small number of cases in the second Boston cohort.
Han Chinese polycystic ovary syndrome risk variants in women of European ancestry: relationship to FSH levels and glucose tolerance.
2015-04-22
0.000212
3
A variant rs705702-G near RAB5B and SUOX was associated with insulin -0.16 ± 0.05, P = 0.0029 and glucose levels -0.20 ± 0.05, P = 0.0002 120 min after an oral glucose test.The study was large and contained replication cohorts, but was limited by a small number of controls in the Greek cohort and a small number of cases in the second Boston cohort.
DENND1A gene variants in Bahraini Arab women with polycystic ovary syndrome.
2015-01-24
0.05
5
The outcome was that the minor allele frequencies of SNPs rs10818854, rs2479106, and rs10986105 were similar between women with PCOS and control women P>0.05, even before correcting for multiple testing, and none of the tested DENND1A SNPs were associated with PCOS under co-dominant, dominant, or recessive genetic models.
DENND1A gene variants in Bahraini Arab women with polycystic ovary syndrome.
2015-01-24
0.05
15
The outcome was that the minor allele frequencies of SNPs rs10818854, rs2479106, and rs10986105 were similar between women with PCOS and control women P>0.05, even before correcting for multiple testing, and none of the tested DENND1A SNPs were associated with PCOS under co-dominant, dominant, or recessive genetic models.
DENND1A gene variants in Bahraini Arab women with polycystic ovary syndrome.
2015-01-24
0.05
1
The outcome was that the minor allele frequencies of SNPs rs10818854, rs2479106, and rs10986105 were similar between women with PCOS and control women P>0.05, even before correcting for multiple testing, and none of the tested DENND1A SNPs were associated with PCOS under co-dominant, dominant, or recessive genetic models.
The association between polymorphism of INSR and polycystic ovary syndrome: a meta-analysis.
2015-01-22
0.05
3
Twelve studies including 1158 controls and 1264 PCOS cases entered the analysis of rs1799817, but no significant association was found for every genotype p > 0.05.
The association between polymorphism of INSR and polycystic ovary syndrome: a meta-analysis.
2015-01-22
0.05
1
For rs2059806, four studies including 442 controls and 524 PCOS cases were qualified for meta-analysis, and no significant association with PCOS was found for any genotype p > 0.05.
Genome-wide association study identified new susceptibility loci for polycystic ovary syndrome.
2015-01-08
5.46e-08
0.52
2
The strongest association was on chromosome 8q24.2 rs10505648, OR = 0.52, P = 5.46 × 10-8, and other association signals were located at 4q35.2, 16p13.3, 4p12, 3q26.33, 9q21.32, 11p13 and 1p22 P = 5.72 × 10-6-6.43 × 10-5.
Genome-wide association study identified new susceptibility loci for polycystic ovary syndrome.
2015-01-08
5.72e-06
2
The strongest association was on chromosome 8q24.2 rs10505648, OR = 0.52, P = 5.46 × 10-8, and other association signals were located at 4q35.2, 16p13.3, 4p12, 3q26.33, 9q21.32, 11p13 and 1p22 P = 5.72 × 10-6-6.43 × 10-5.
[Family-based analysis of the adiponectin gene polymorphisms and polycystic ovary syndrome].
0.008
10
The transmission disequilibrium test TDT was used to analyze the association between three SNP of ADIPOQ and PCOS.1 A significant positive association was detected between SNP rs1501299 and PCOS χ² = 7.093, P = 0.008.
[Family-based analysis of the adiponectin gene polymorphisms and polycystic ovary syndrome].
0.203
9
However we failed to find significant overtransmission of the other two SNP rs2241766 and rs12495941 from parents to PCOS offsprings χ² = 1.620, P = 0.203; χ² = 0.713, P = 0.398.
[Family-based analysis of the adiponectin gene polymorphisms and polycystic ovary syndrome].
0.398
4
However we failed to find significant overtransmission of the other two SNP rs2241766 and rs12495941 from parents to PCOS offsprings χ² = 1.620, P = 0.203; χ² = 0.713, P = 0.398.
[Family-based analysis of the adiponectin gene polymorphisms and polycystic ovary syndrome].
0.05
10
The genotype frequencies of the three SNP were not different in obese and lean PCOS patients and their parents P>0.05.TDT confirms that SNP rs1501299 in the ADIPOQ is significantly associated with the risk of PCOS in the Chinese Han population.
Family association study between tumour necrosis factor a gene polymorphisms and polycystic ovary syndrome in Han Chinese.
2014-07-21
0.0013
4
A significant difference in transmission was found for rs1799964 transmitted: non-transmitted = 73 : 39; χ2 = 10.321; P = 0.0013. rs1799724 showed no evidence of an association with PCOS; risk alleles were over transmitted transmitted: non-transmitted = 43 : 33; χ2 = 1.316.
Family association study between tumour necrosis factor a gene polymorphisms and polycystic ovary syndrome in Han Chinese.
2014-07-21
0.0013
1
A significant difference in transmission was found for rs1799964 transmitted: non-transmitted = 73 : 39; χ2 = 10.321; P = 0.0013. rs1799724 showed no evidence of an association with PCOS; risk alleles were over transmitted transmitted: non-transmitted = 43 : 33; χ2 = 1.316.
[Correlation analysis between polycystic ovary syndrome susceptibility genes and metabolic phenotypes].
0.01
8
To investigate the relationship between polycystic ovary syndrome PCOS susceptibility single nucleotide polymorphisms SNP and metabolic phenotypes in glucose and lipid metabolism and explore the pathophysiological mechanism of the susceptibility genes.Three of PCOS susceptibility locus 2p16.3 rs13405728 of LHCGR gene, 2p21 rs13429458, rs12478601 of THADA gene and 9q33.3 rs2479106, rs10818854 of DENNDIA gene were selected and the metabolic phenotypes were compared between different genotypes of SNP in PCOS patients using dominant model.Low-density lipoprotein cholesterol was significantly increased in CC genotype group than in TC + TT groups at rs12478601 of THADA gene [2.5 ± 0.8, 2.4 ± 0.8 mmol/L; P = 0.01].
[Correlation analysis between polycystic ovary syndrome susceptibility genes and metabolic phenotypes].
0.01
8
To investigate the relationship between polycystic ovary syndrome PCOS susceptibility single nucleotide polymorphisms SNP and metabolic phenotypes in glucose and lipid metabolism and explore the pathophysiological mechanism of the susceptibility genes.Three of PCOS susceptibility locus 2p16.3 rs13405728 of LHCGR gene, 2p21 rs13429458, rs12478601 of THADA gene and 9q33.3 rs2479106, rs10818854 of DENNDIA gene were selected and the metabolic phenotypes were compared between different genotypes of SNP in PCOS patients using dominant model.Low-density lipoprotein cholesterol was significantly increased in CC genotype group than in TC + TT groups at rs12478601 of THADA gene [2.5 ± 0.8, 2.4 ± 0.8 mmol/L; P = 0.01].
[Correlation analysis between polycystic ovary syndrome susceptibility genes and metabolic phenotypes].
0.01
4
To investigate the relationship between polycystic ovary syndrome PCOS susceptibility single nucleotide polymorphisms SNP and metabolic phenotypes in glucose and lipid metabolism and explore the pathophysiological mechanism of the susceptibility genes.Three of PCOS susceptibility locus 2p16.3 rs13405728 of LHCGR gene, 2p21 rs13429458, rs12478601 of THADA gene and 9q33.3 rs2479106, rs10818854 of DENNDIA gene were selected and the metabolic phenotypes were compared between different genotypes of SNP in PCOS patients using dominant model.Low-density lipoprotein cholesterol was significantly increased in CC genotype group than in TC + TT groups at rs12478601 of THADA gene [2.5 ± 0.8, 2.4 ± 0.8 mmol/L; P = 0.01].
[Correlation analysis between polycystic ovary syndrome susceptibility genes and metabolic phenotypes].
0.01
15
To investigate the relationship between polycystic ovary syndrome PCOS susceptibility single nucleotide polymorphisms SNP and metabolic phenotypes in glucose and lipid metabolism and explore the pathophysiological mechanism of the susceptibility genes.Three of PCOS susceptibility locus 2p16.3 rs13405728 of LHCGR gene, 2p21 rs13429458, rs12478601 of THADA gene and 9q33.3 rs2479106, rs10818854 of DENNDIA gene were selected and the metabolic phenotypes were compared between different genotypes of SNP in PCOS patients using dominant model.Low-density lipoprotein cholesterol was significantly increased in CC genotype group than in TC + TT groups at rs12478601 of THADA gene [2.5 ± 0.8, 2.4 ± 0.8 mmol/L; P = 0.01].
[Correlation analysis between polycystic ovary syndrome susceptibility genes and metabolic phenotypes].
0.01
5
To investigate the relationship between polycystic ovary syndrome PCOS susceptibility single nucleotide polymorphisms SNP and metabolic phenotypes in glucose and lipid metabolism and explore the pathophysiological mechanism of the susceptibility genes.Three of PCOS susceptibility locus 2p16.3 rs13405728 of LHCGR gene, 2p21 rs13429458, rs12478601 of THADA gene and 9q33.3 rs2479106, rs10818854 of DENNDIA gene were selected and the metabolic phenotypes were compared between different genotypes of SNP in PCOS patients using dominant model.Low-density lipoprotein cholesterol was significantly increased in CC genotype group than in TC + TT groups at rs12478601 of THADA gene [2.5 ± 0.8, 2.4 ± 0.8 mmol/L; P = 0.01].
[Correlation analysis between polycystic ovary syndrome susceptibility genes and metabolic phenotypes].
0.01
4
To investigate the relationship between polycystic ovary syndrome PCOS susceptibility single nucleotide polymorphisms SNP and metabolic phenotypes in glucose and lipid metabolism and explore the pathophysiological mechanism of the susceptibility genes.Three of PCOS susceptibility locus 2p16.3 rs13405728 of LHCGR gene, 2p21 rs13429458, rs12478601 of THADA gene and 9q33.3 rs2479106, rs10818854 of DENNDIA gene were selected and the metabolic phenotypes were compared between different genotypes of SNP in PCOS patients using dominant model.Low-density lipoprotein cholesterol was significantly increased in CC genotype group than in TC + TT groups at rs12478601 of THADA gene [2.5 ± 0.8, 2.4 ± 0.8 mmol/L; P = 0.01].
[Correlation analysis between polycystic ovary syndrome susceptibility genes and metabolic phenotypes].
0.05
15
Serum insulin level of 2 hours after 75 g glucose intake was significantly higher in GG+AG groups than that of AA group at rs2479106 of DENND1A gene[71 ± 65, 64 ± 50 mU/L; P = 0.05 ], and the prevalence of type II diabetes in first-degree relatives of patients were also increased [9.9% 66/666, 6.9% 52/751; P < 0.05].
[Correlation analysis between polycystic ovary syndrome susceptibility genes and metabolic phenotypes].
0.05
15
Serum insulin level of 2 hours after 75 g glucose intake was significantly higher in GG+AG groups than that of AA group at rs2479106 of DENND1A gene[71 ± 65, 64 ± 50 mU/L; P = 0.05 ], and the prevalence of type II diabetes in first-degree relatives of patients were also increased [9.9% 66/666, 6.9% 52/751; P < 0.05].
Associations of single nucleotide polymorphisms related to insulin resistance with polycystic ovary syndrome.
0.03
1
The rs1719889 showed significant association with fasting glucose level p=0.03.Our results provide evidence for the relationship between high prevalence of insulin resistance and PCOS.
Trp28Arg/Ile35Thr LHB gene variants are associated with elevated testosterone levels in women with polycystic ovary syndrome.
2014-08-08
0.02
2
Two polymorphisms in linkage disequilibrium were significantly more prevalent in the presence of hyperandrogenemia: rs1800447/rs34349826 Trp28Arg/Ile35Thr p=0.02.In this series, a modulatory effect of LHB polymorphisms on hyperandrogenemia phenotype of PCOS was observed; however, this finding needs to be replicated in other populations.
Trp28Arg/Ile35Thr LHB gene variants are associated with elevated testosterone levels in women with polycystic ovary syndrome.
2014-08-08
0.02
2
Two polymorphisms in linkage disequilibrium were significantly more prevalent in the presence of hyperandrogenemia: rs1800447/rs34349826 Trp28Arg/Ile35Thr p=0.02.In this series, a modulatory effect of LHB polymorphisms on hyperandrogenemia phenotype of PCOS was observed; however, this finding needs to be replicated in other populations.
Selected CNR1 polymorphisms and hyperandrogenemia as well as fat mass and fat distribution in women with polycystic ovary syndrome.
2014-08-05
0.0344
3.01
1
We observed a significantly three times higher risk of GG genotype in the polymorphism rs12720071 in women with PCOS versus the control group p = 0.0344, OR = 3.01.
Genetic polymorphisms of TCF7L2 lack influence on risk of the polycystic ovary syndrome - a systemic analysis.
0.05
1.06
9
For TCF7L2 rs7903146, a non-significant slight increase in risk of PCOS development was observed under three genetic models dominant model: OR=1.06, 95%CI: 0.93-1.21, p>0.05; recessive model: OR=1.12, 95%CI: 0.87-1.43, p> 0.05; homozygous model: OR=1.14, 95%CI: 0.87-1.47, p>0.05.
Genetic polymorphisms of TCF7L2 lack influence on risk of the polycystic ovary syndrome - a systemic analysis.
0.05
1.12
9
For TCF7L2 rs7903146, a non-significant slight increase in risk of PCOS development was observed under three genetic models dominant model: OR=1.06, 95%CI: 0.93-1.21, p>0.05; recessive model: OR=1.12, 95%CI: 0.87-1.43, p> 0.05; homozygous model: OR=1.14, 95%CI: 0.87-1.47, p>0.05.
Genetic polymorphisms of TCF7L2 lack influence on risk of the polycystic ovary syndrome - a systemic analysis.
0.05
1.14
9
For TCF7L2 rs7903146, a non-significant slight increase in risk of PCOS development was observed under three genetic models dominant model: OR=1.06, 95%CI: 0.93-1.21, p>0.05; recessive model: OR=1.12, 95%CI: 0.87-1.43, p> 0.05; homozygous model: OR=1.14, 95%CI: 0.87-1.47, p>0.05.
Genetic polymorphisms of TCF7L2 lack influence on risk of the polycystic ovary syndrome - a systemic analysis.
0.05
1.00
9
In the subgroup analyses in Asian group, allele susceptibility of PCOS was calculated allele model: OR=1.00, 95%CI: 0.74-1.35, p>0.05; dominant model: OR=0.98, 95%CI: 0.71-1.35, p>0.05; recessive model: OR=1.79, 95%CI: 0.33-9.84, p>0.05; homozygous model: OR=1.78, 95%CI: 0.32-9.80, p>0.05, the differences were again not statistically significant.The findings of this systemic analysis suggest that the polymorphism of TCF7L2 rs7903146 may not be associated with the susceptibility to PCOS.
Genetic polymorphisms of TCF7L2 lack influence on risk of the polycystic ovary syndrome - a systemic analysis.
0.05
0.98
9
In the subgroup analyses in Asian group, allele susceptibility of PCOS was calculated allele model: OR=1.00, 95%CI: 0.74-1.35, p>0.05; dominant model: OR=0.98, 95%CI: 0.71-1.35, p>0.05; recessive model: OR=1.79, 95%CI: 0.33-9.84, p>0.05; homozygous model: OR=1.78, 95%CI: 0.32-9.80, p>0.05, the differences were again not statistically significant.The findings of this systemic analysis suggest that the polymorphism of TCF7L2 rs7903146 may not be associated with the susceptibility to PCOS.
Genetic polymorphisms of TCF7L2 lack influence on risk of the polycystic ovary syndrome - a systemic analysis.
0.05
1.79
9
In the subgroup analyses in Asian group, allele susceptibility of PCOS was calculated allele model: OR=1.00, 95%CI: 0.74-1.35, p>0.05; dominant model: OR=0.98, 95%CI: 0.71-1.35, p>0.05; recessive model: OR=1.79, 95%CI: 0.33-9.84, p>0.05; homozygous model: OR=1.78, 95%CI: 0.32-9.80, p>0.05, the differences were again not statistically significant.The findings of this systemic analysis suggest that the polymorphism of TCF7L2 rs7903146 may not be associated with the susceptibility to PCOS.
Genetic polymorphisms of TCF7L2 lack influence on risk of the polycystic ovary syndrome - a systemic analysis.
0.05
1.78
9
In the subgroup analyses in Asian group, allele susceptibility of PCOS was calculated allele model: OR=1.00, 95%CI: 0.74-1.35, p>0.05; dominant model: OR=0.98, 95%CI: 0.71-1.35, p>0.05; recessive model: OR=1.79, 95%CI: 0.33-9.84, p>0.05; homozygous model: OR=1.78, 95%CI: 0.32-9.80, p>0.05, the differences were again not statistically significant.The findings of this systemic analysis suggest that the polymorphism of TCF7L2 rs7903146 may not be associated with the susceptibility to PCOS.
Association between adiponectin receptor 1 gene polymorphism and insulin resistance in Chinese patients with polycystic ovary syndrome.
2013-12-03
0.05
1
1
The fasting insulin levels in subjects with the GG genotype were significantly higher than those in patients with the AA genotype p < 0.05.SNP rs1539355 in the ADIPOR1 gene is associated with insulin resistance in Chinese PCOS patients.
Polymorphisms of transcription factor-7-like 2 (TCF7L2) gene in Tunisian women with polycystic ovary syndrome (PCOS).
2013-10-22
0.61
2
TCF7L2 genotyping was done by the allelic discrimination/real-time PCR method.Minor allele frequencies MAFs of rs4506565 P=0.61, rs7903146 P=0.68, rs12243326 P=0.56, and rs12255372 P=0.60 were comparable between PCOS cases and control subjects.
Polymorphisms of transcription factor-7-like 2 (TCF7L2) gene in Tunisian women with polycystic ovary syndrome (PCOS).
2013-10-22
0.68
9
TCF7L2 genotyping was done by the allelic discrimination/real-time PCR method.Minor allele frequencies MAFs of rs4506565 P=0.61, rs7903146 P=0.68, rs12243326 P=0.56, and rs12255372 P=0.60 were comparable between PCOS cases and control subjects.
Polymorphisms of transcription factor-7-like 2 (TCF7L2) gene in Tunisian women with polycystic ovary syndrome (PCOS).
2013-10-22
0.56
2
TCF7L2 genotyping was done by the allelic discrimination/real-time PCR method.Minor allele frequencies MAFs of rs4506565 P=0.61, rs7903146 P=0.68, rs12243326 P=0.56, and rs12255372 P=0.60 were comparable between PCOS cases and control subjects.
Polymorphisms of transcription factor-7-like 2 (TCF7L2) gene in Tunisian women with polycystic ovary syndrome (PCOS).
2013-10-22
0.6
2
TCF7L2 genotyping was done by the allelic discrimination/real-time PCR method.Minor allele frequencies MAFs of rs4506565 P=0.61, rs7903146 P=0.68, rs12243326 P=0.56, and rs12255372 P=0.60 were comparable between PCOS cases and control subjects.
Polymorphisms of transcription factor-7-like 2 (TCF7L2) gene in Tunisian women with polycystic ovary syndrome (PCOS).
2013-10-22
0.035
95
2
As the four tested TCF7L2 variants were in linkage disequilibrium, 4-locus rs4506565, rs7903146, rs12243326, rs12255372 haplotype analysis demonstrated that haplotype 2111 was initially negatively associated with PCOS [P=0.035; OR 95% CI=0.13 0.02-0.85], which was later lost upon correcting for multiple comparisons [Pc=0.248].Our data suggest that there is weak or no contribution of TCF7L2 gene polymorphism to PCOS in Tunisian women.
Polymorphisms of transcription factor-7-like 2 (TCF7L2) gene in Tunisian women with polycystic ovary syndrome (PCOS).
2013-10-22
0.035
9
As the four tested TCF7L2 variants were in linkage disequilibrium, 4-locus rs4506565, rs7903146, rs12243326, rs12255372 haplotype analysis demonstrated that haplotype 2111 was initially negatively associated with PCOS [P=0.035; OR 95% CI=0.13 0.02-0.85], which was later lost upon correcting for multiple comparisons [Pc=0.248].Our data suggest that there is weak or no contribution of TCF7L2 gene polymorphism to PCOS in Tunisian women.
Polymorphisms of transcription factor-7-like 2 (TCF7L2) gene in Tunisian women with polycystic ovary syndrome (PCOS).
2013-10-22
0.035
2
As the four tested TCF7L2 variants were in linkage disequilibrium, 4-locus rs4506565, rs7903146, rs12243326, rs12255372 haplotype analysis demonstrated that haplotype 2111 was initially negatively associated with PCOS [P=0.035; OR 95% CI=0.13 0.02-0.85], which was later lost upon correcting for multiple comparisons [Pc=0.248].Our data suggest that there is weak or no contribution of TCF7L2 gene polymorphism to PCOS in Tunisian women.
Polymorphisms of transcription factor-7-like 2 (TCF7L2) gene in Tunisian women with polycystic ovary syndrome (PCOS).
2013-10-22
0.035
2
As the four tested TCF7L2 variants were in linkage disequilibrium, 4-locus rs4506565, rs7903146, rs12243326, rs12255372 haplotype analysis demonstrated that haplotype 2111 was initially negatively associated with PCOS [P=0.035; OR 95% CI=0.13 0.02-0.85], which was later lost upon correcting for multiple comparisons [Pc=0.248].Our data suggest that there is weak or no contribution of TCF7L2 gene polymorphism to PCOS in Tunisian women.
TNF-α haplotype association with polycystic ovary syndrome - a South Indian study.
2013-08-23
0.001
4
Following extraction of DNA, genotyping for rs1800629 and rs1799964 was performed by polymerase chain reaction using tetra primers and PCR-RFLP respectively.The distribution of genotypes for rs1799964 was significantly different between the groups p = 0.001, however it was not for rs1800629.
TNF-α haplotype association with polycystic ovary syndrome - a South Indian study.
2013-08-23
0.001
4
Following extraction of DNA, genotyping for rs1800629 and rs1799964 was performed by polymerase chain reaction using tetra primers and PCR-RFLP respectively.The distribution of genotypes for rs1799964 was significantly different between the groups p = 0.001, however it was not for rs1800629.
TNF-α haplotype association with polycystic ovary syndrome - a South Indian study.
2013-08-23
0.001
4
Following extraction of DNA, genotyping for rs1800629 and rs1799964 was performed by polymerase chain reaction using tetra primers and PCR-RFLP respectively.The distribution of genotypes for rs1799964 was significantly different between the groups p = 0.001, however it was not for rs1800629.
TNF-α haplotype association with polycystic ovary syndrome - a South Indian study.
2013-08-23
0.001
4
Following extraction of DNA, genotyping for rs1800629 and rs1799964 was performed by polymerase chain reaction using tetra primers and PCR-RFLP respectively.The distribution of genotypes for rs1799964 was significantly different between the groups p = 0.001, however it was not for rs1800629.
Common variant rs9939609 in gene FTO confers risk to polycystic ovary syndrome.
2013-07-01
0.00247
13
All subjects are from Han Chinese.The less meaningful association of FTO rs9939609 and PCOS discovered in GWAS P = 2.47E-03, was further confirmed in the replication study P = 1.86E-09.
Common variant rs9939609 in gene FTO confers risk to polycystic ovary syndrome.
2013-07-01
1.86e-09
13
All subjects are from Han Chinese.The less meaningful association of FTO rs9939609 and PCOS discovered in GWAS P = 2.47E-03, was further confirmed in the replication study P = 1.86E-09.
Genotype-phenotype correlations of PCOS susceptibility SNPs identified by GWAS in a large cohort of Han Chinese women.
2012-12-02
0.01
8
Endocrine and metabolic parameters were evaluated for phenotype-genotype correlation analyses.Using a recessive model, the AA group for rs13429458 in THADA was associated with increased luteinizing hormone LH P < 0.01 and testosterone T P = 0.02 levels in subjects with PCOS; the LH/follicle-stimulating hormone ratio was also higher in the AA group P < 0.01.
Genotype-phenotype correlations of PCOS susceptibility SNPs identified by GWAS in a large cohort of Han Chinese women.
2012-12-02
0.02
8
Endocrine and metabolic parameters were evaluated for phenotype-genotype correlation analyses.Using a recessive model, the AA group for rs13429458 in THADA was associated with increased luteinizing hormone LH P < 0.01 and testosterone T P = 0.02 levels in subjects with PCOS; the LH/follicle-stimulating hormone ratio was also higher in the AA group P < 0.01.
Genotype-phenotype correlations of PCOS susceptibility SNPs identified by GWAS in a large cohort of Han Chinese women.
2012-12-02
0.01
8
Endocrine and metabolic parameters were evaluated for phenotype-genotype correlation analyses.Using a recessive model, the AA group for rs13429458 in THADA was associated with increased luteinizing hormone LH P < 0.01 and testosterone T P = 0.02 levels in subjects with PCOS; the LH/follicle-stimulating hormone ratio was also higher in the AA group P < 0.01.
Genotype-phenotype correlations of PCOS susceptibility SNPs identified by GWAS in a large cohort of Han Chinese women.
2012-12-02
0.02
15
Using a dominant model, the GG + AG group for rs2479106 in DENND1A was associated with elevated serum insulin levels 2 h after a glucose load in the patients with PCOS P = 0.02.
Evidence for chromosome 2p16.3 polycystic ovary syndrome susceptibility locus in affected women of European ancestry.
2012-11-01
0.0037
1
A previous genome-wide association study in Chinese women with polycystic ovary syndrome PCOS identified a region on chromosome 2p16.3 encoding the LH/choriogonadotropin receptor LHCGR and FSH receptor FSHR genes as a reproducible PCOS susceptibility locus.The objective of the study was to determine the role of the LHCGR and/or FSHR gene in the etiology of PCOS in women of European ancestry.This was a genetic association study in a European ancestry cohort of women with PCOS.The study was conducted at an academic medical center.Participants in the study included 905 women with PCOS diagnosed by National Institutes of Health criteria and 956 control women.We genotyped 94 haplotype-tagging single-nucleotide polymorphisms and two coding single-nucleotide polymorphisms mapping to the coding region of LHCGR and FSHR plus 20 kb upstream and downstream of the genes and test for association in the case control cohort and for association with nine quantitative traits in the women with PCOS.We found strong evidence for an association of PCOS with rs7562215 P = 0.0037 and rs10495960 P = 0.0046.
Evidence for chromosome 2p16.3 polycystic ovary syndrome susceptibility locus in affected women of European ancestry.
2012-11-01
0.0046
1
A previous genome-wide association study in Chinese women with polycystic ovary syndrome PCOS identified a region on chromosome 2p16.3 encoding the LH/choriogonadotropin receptor LHCGR and FSH receptor FSHR genes as a reproducible PCOS susceptibility locus.The objective of the study was to determine the role of the LHCGR and/or FSHR gene in the etiology of PCOS in women of European ancestry.This was a genetic association study in a European ancestry cohort of women with PCOS.The study was conducted at an academic medical center.Participants in the study included 905 women with PCOS diagnosed by National Institutes of Health criteria and 956 control women.We genotyped 94 haplotype-tagging single-nucleotide polymorphisms and two coding single-nucleotide polymorphisms mapping to the coding region of LHCGR and FSHR plus 20 kb upstream and downstream of the genes and test for association in the case control cohort and for association with nine quantitative traits in the women with PCOS.We found strong evidence for an association of PCOS with rs7562215 P = 0.0037 and rs10495960 P = 0.0046.
Association study of gene LPP in women with polycystic ovary syndrome.
2012-10-03
1.89e-05
1.23
2
Genotyping of LPP gene was carried out by Taqman-MGB method.In rs715790, the allele frequency is significantly different between the PCOS group and the control group Meta-analysis showed that the allele frequencies of the three SNPs rs715790 Pmeta =1.89E-05, OR=1.23, rs4449306 Pmeta =3.0E-04, OR=1.10, rs6782041 Pmeta = 2.0E-04, OR=1.09, were significantly different between PCOS cases and controls.Our results suggest that LPP gene might be a novel candidate for PCOS.
Association study of gene LPP in women with polycystic ovary syndrome.
2012-10-03
0.0003
1.10
2
Genotyping of LPP gene was carried out by Taqman-MGB method.In rs715790, the allele frequency is significantly different between the PCOS group and the control group Meta-analysis showed that the allele frequencies of the three SNPs rs715790 Pmeta =1.89E-05, OR=1.23, rs4449306 Pmeta =3.0E-04, OR=1.10, rs6782041 Pmeta = 2.0E-04, OR=1.09, were significantly different between PCOS cases and controls.Our results suggest that LPP gene might be a novel candidate for PCOS.
Association study of gene LPP in women with polycystic ovary syndrome.
2012-10-03
0.0002
1.09
1
Genotyping of LPP gene was carried out by Taqman-MGB method.In rs715790, the allele frequency is significantly different between the PCOS group and the control group Meta-analysis showed that the allele frequencies of the three SNPs rs715790 Pmeta =1.89E-05, OR=1.23, rs4449306 Pmeta =3.0E-04, OR=1.10, rs6782041 Pmeta = 2.0E-04, OR=1.09, were significantly different between PCOS cases and controls.Our results suggest that LPP gene might be a novel candidate for PCOS.
Variants in DENND1A and LHCGR are associated with endometrioid adenocarcinoma.
2012-08-14
0.05
15
The effects of body mass index BMI and age were evaluated using an unconditional logistic regression model adjusted for potential confounders.The allele frequencies of SNPs rs2479106 and rs13405728 were significantly different P<0.05 between endometrial carcinoma group and control group, and the difference was especially significant in the subgroup of endometrioid adenocarcinoma.
Steroidogenic regulatory factor FOS is underexpressed in polycystic ovary syndrome (PCOS) adipose tissue and genetically associated with PCOS susceptibility.
2012-06-21
0.0031
2
Three single-nucleotide polymorphisms were significantly associated with PCOS in the discovery cohort rs8006998, P = 0.0031; rs8013918, P = 0.0006; rs8013942, P = 0.0087. rs8006998 was also associated with PCOS in the replication cohort P = 0.013.Differential gene expression in sc fat and genetic association at the FOS locus in PCOS subjects implicates a role for this transcription factor in PCOS.
Steroidogenic regulatory factor FOS is underexpressed in polycystic ovary syndrome (PCOS) adipose tissue and genetically associated with PCOS susceptibility.
2012-06-21
0.0006
1
Three single-nucleotide polymorphisms were significantly associated with PCOS in the discovery cohort rs8006998, P = 0.0031; rs8013918, P = 0.0006; rs8013942, P = 0.0087. rs8006998 was also associated with PCOS in the replication cohort P = 0.013.Differential gene expression in sc fat and genetic association at the FOS locus in PCOS subjects implicates a role for this transcription factor in PCOS.
Steroidogenic regulatory factor FOS is underexpressed in polycystic ovary syndrome (PCOS) adipose tissue and genetically associated with PCOS susceptibility.
2012-06-21
0.0087
1
Three single-nucleotide polymorphisms were significantly associated with PCOS in the discovery cohort rs8006998, P = 0.0031; rs8013918, P = 0.0006; rs8013942, P = 0.0087. rs8006998 was also associated with PCOS in the replication cohort P = 0.013.Differential gene expression in sc fat and genetic association at the FOS locus in PCOS subjects implicates a role for this transcription factor in PCOS.
Steroidogenic regulatory factor FOS is underexpressed in polycystic ovary syndrome (PCOS) adipose tissue and genetically associated with PCOS susceptibility.
2012-06-21
0.013
2
Three single-nucleotide polymorphisms were significantly associated with PCOS in the discovery cohort rs8006998, P = 0.0031; rs8013918, P = 0.0006; rs8013942, P = 0.0087. rs8006998 was also associated with PCOS in the replication cohort P = 0.013.Differential gene expression in sc fat and genetic association at the FOS locus in PCOS subjects implicates a role for this transcription factor in PCOS.
Association between polymorphisms of the CYP11A1 gene and polycystic ovary syndrome in Chinese women.
2012-06-15
0.001
3
Combined analysis a total of 1262 participants, including 604 PCOS patients and 658 control women showed a much more significant difference in the genotypic distribution of rs4077582 between PCOS and controls P < 0.001.
Variants in DENND1A are associated with polycystic ovary syndrome in women of European ancestry.
2012-04-30
0.00033
1.68
1
Controls were 16,947, 483, and 189 women not known to have PCOS from Iceland, Boston, and Chicago, respectively.There were no interventions.Main outcomes were allele frequencies for seven variants in PCOS cases and controls.Two strongly correlated Han Chinese PCOS risk variants on chromosome 9q33.3, rs10986105[C], and rs10818854[A], were replicated in samples of European ancestry with odds ratio of 1.68 P = 0.00033 and odds ratio of 1.53 P = 0.0019, respectively.
Variants in DENND1A are associated with polycystic ovary syndrome in women of European ancestry.
2012-04-30
0.0019
1.53
1
Controls were 16,947, 483, and 189 women not known to have PCOS from Iceland, Boston, and Chicago, respectively.There were no interventions.Main outcomes were allele frequencies for seven variants in PCOS cases and controls.Two strongly correlated Han Chinese PCOS risk variants on chromosome 9q33.3, rs10986105[C], and rs10818854[A], were replicated in samples of European ancestry with odds ratio of 1.68 P = 0.00033 and odds ratio of 1.53 P = 0.0019, respectively.
Association of the genetic variants of luteinizing hormone, luteinizing hormone receptor and polycystic ovary syndrome.
2012-04-30
0.001
1
The aim of this study was determine the role of the LH and LHR polymorphisms in the pathogenesis of PCOS using a genetic approach.315 PCOS women and 212 controls were screened for the gene variants of LH G1052A and LHR rs61996318 polymorphisms by polymerase chain reaction restriction fragment length polymorphism PCR-RFLP.PCOS patients had significantly more A allele frequency of LH G1052A mutations than controls p=0.001.
Identification of YAP1 as a novel susceptibility gene for polycystic ovary syndrome.
3.98e-09
1
Real-time quantitative PCR was applied for genotyping by TaqMan-MGB probe assay.Meta-analysis showed that the allele frequency of rs11225161 A/G was significantly different between PCOS and controls at a GWA significance Pmeta =3.98e-09.
Identification of YAP1 as a novel susceptibility gene for polycystic ovary syndrome.
0.041
1
The G allele of SNP rs11225138 G/C was a further risk factor for higher luteinising hormone level in PCOS patients p=0.041.YAP1 appears to be a new susceptibility gene for PCOS in Han Chinese women.
Family-based analysis of susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3.
2011-11-10
3.74e-05
8
The transmission disequilibrium test TDT was used to analyze the association between PCOS and five SNPs rs13429458, rs12478601, rs13405728, rs10818854 and rs2479106 in three susceptible loci 2p16.3, 2p21 and 9q33.3.A positive association was observed for the SNP rs13429458 P= 3.74 × 10-5.TDT confirms that SNP rs13429458, in the THADA gene, is significantly associated with risk of PCOS.
Family-based analysis of susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3.
2011-11-10
3.74e-05
4
The transmission disequilibrium test TDT was used to analyze the association between PCOS and five SNPs rs13429458, rs12478601, rs13405728, rs10818854 and rs2479106 in three susceptible loci 2p16.3, 2p21 and 9q33.3.A positive association was observed for the SNP rs13429458 P= 3.74 × 10-5.TDT confirms that SNP rs13429458, in the THADA gene, is significantly associated with risk of PCOS.
Family-based analysis of susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3.
2011-11-10
3.74e-05
8
The transmission disequilibrium test TDT was used to analyze the association between PCOS and five SNPs rs13429458, rs12478601, rs13405728, rs10818854 and rs2479106 in three susceptible loci 2p16.3, 2p21 and 9q33.3.A positive association was observed for the SNP rs13429458 P= 3.74 × 10-5.TDT confirms that SNP rs13429458, in the THADA gene, is significantly associated with risk of PCOS.
Family-based analysis of susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3.
2011-11-10
3.74e-05
5
The transmission disequilibrium test TDT was used to analyze the association between PCOS and five SNPs rs13429458, rs12478601, rs13405728, rs10818854 and rs2479106 in three susceptible loci 2p16.3, 2p21 and 9q33.3.A positive association was observed for the SNP rs13429458 P= 3.74 × 10-5.TDT confirms that SNP rs13429458, in the THADA gene, is significantly associated with risk of PCOS.
Family-based analysis of susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3.
2011-11-10
3.74e-05
15
The transmission disequilibrium test TDT was used to analyze the association between PCOS and five SNPs rs13429458, rs12478601, rs13405728, rs10818854 and rs2479106 in three susceptible loci 2p16.3, 2p21 and 9q33.3.A positive association was observed for the SNP rs13429458 P= 3.74 × 10-5.TDT confirms that SNP rs13429458, in the THADA gene, is significantly associated with risk of PCOS.
Family-based analysis of susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3.
2011-11-10
3.74e-05
8
The transmission disequilibrium test TDT was used to analyze the association between PCOS and five SNPs rs13429458, rs12478601, rs13405728, rs10818854 and rs2479106 in three susceptible loci 2p16.3, 2p21 and 9q33.3.A positive association was observed for the SNP rs13429458 P= 3.74 × 10-5.TDT confirms that SNP rs13429458, in the THADA gene, is significantly associated with risk of PCOS.
Family-based analysis of susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3.
2011-11-10
3.74e-05
8
The transmission disequilibrium test TDT was used to analyze the association between PCOS and five SNPs rs13429458, rs12478601, rs13405728, rs10818854 and rs2479106 in three susceptible loci 2p16.3, 2p21 and 9q33.3.A positive association was observed for the SNP rs13429458 P= 3.74 × 10-5.TDT confirms that SNP rs13429458, in the THADA gene, is significantly associated with risk of PCOS.
Susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21, and 9q33.3 in a cohort of Caucasian women.
2011-10-18
0.034
15
PCOS women with the rs2479106 GG genotype had significantly higher WHR than PCOS women carrying the AG and AA genotype p=0.034 and p=0.020, respectively.
Susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21, and 9q33.3 in a cohort of Caucasian women.
2011-10-18
0.02
15
PCOS women with the rs2479106 GG genotype had significantly higher WHR than PCOS women carrying the AG and AA genotype p=0.034 and p=0.020, respectively.
Susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21, and 9q33.3 in a cohort of Caucasian women.
2011-10-18
0.024
15
Moreover, QChol/HDL and LDL levels were significantly higher in PCOS women carrying the rs2479106 GG genotype when compared to those carrying the AA genotype p=0.024 and p=0.035, respectively.
Susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21, and 9q33.3 in a cohort of Caucasian women.
2011-10-18
0.035
15
Moreover, QChol/HDL and LDL levels were significantly higher in PCOS women carrying the rs2479106 GG genotype when compared to those carrying the AA genotype p=0.024 and p=0.035, respectively.
Susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21, and 9q33.3 in a cohort of Caucasian women.
2011-10-18
0.039
8
PCOS women carrying the G allele of rs13405728 had significantly higher AUCgluc, glucose-30 min, and AUCins levels than those carrying the AA genotype p=0.039, p=0.047, and p=0.044, respectively.
Susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21, and 9q33.3 in a cohort of Caucasian women.
2011-10-18
0.047
8
PCOS women carrying the G allele of rs13405728 had significantly higher AUCgluc, glucose-30 min, and AUCins levels than those carrying the AA genotype p=0.039, p=0.047, and p=0.044, respectively.
Susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21, and 9q33.3 in a cohort of Caucasian women.
2011-10-18
0.044
8
PCOS women carrying the G allele of rs13405728 had significantly higher AUCgluc, glucose-30 min, and AUCins levels than those carrying the AA genotype p=0.039, p=0.047, and p=0.044, respectively.
Family association study between INSR gene polymorphisms and PCOS in Han Chinese.
2011-06-06
0.486
3
In the present study, we investigated the genetic association between polymorphisms in the insulin receptor INSR gene and PCOS.A total of 260 family trios were recruited and performed a family-based analysis to assess linkage and association between four single nucleotide polymorphisms SNPs rs1799817, rs2059807, rs8108622 and rs10500204 of INSR gene and PCOS.Using the transmission disequilibrium test TDT, we failed to find that rs1799817 p = 0.486, rs2059807 p = 0.195, rs8108622 p = 0.866 and rs10500204 p = 1.0 were significantly overtransmitted to PCOS offspring from their parents.No significant evidence of association or linkage was found in the four tested markers, indicating that our family samples did not support susceptibility of the INSR gene to PCOS.
Family association study between INSR gene polymorphisms and PCOS in Han Chinese.
2011-06-06
0.195
1
In the present study, we investigated the genetic association between polymorphisms in the insulin receptor INSR gene and PCOS.A total of 260 family trios were recruited and performed a family-based analysis to assess linkage and association between four single nucleotide polymorphisms SNPs rs1799817, rs2059807, rs8108622 and rs10500204 of INSR gene and PCOS.Using the transmission disequilibrium test TDT, we failed to find that rs1799817 p = 0.486, rs2059807 p = 0.195, rs8108622 p = 0.866 and rs10500204 p = 1.0 were significantly overtransmitted to PCOS offspring from their parents.No significant evidence of association or linkage was found in the four tested markers, indicating that our family samples did not support susceptibility of the INSR gene to PCOS.
Family association study between INSR gene polymorphisms and PCOS in Han Chinese.
2011-06-06
0.866
1
In the present study, we investigated the genetic association between polymorphisms in the insulin receptor INSR gene and PCOS.A total of 260 family trios were recruited and performed a family-based analysis to assess linkage and association between four single nucleotide polymorphisms SNPs rs1799817, rs2059807, rs8108622 and rs10500204 of INSR gene and PCOS.Using the transmission disequilibrium test TDT, we failed to find that rs1799817 p = 0.486, rs2059807 p = 0.195, rs8108622 p = 0.866 and rs10500204 p = 1.0 were significantly overtransmitted to PCOS offspring from their parents.No significant evidence of association or linkage was found in the four tested markers, indicating that our family samples did not support susceptibility of the INSR gene to PCOS.
Family association study between INSR gene polymorphisms and PCOS in Han Chinese.
2011-06-06
1.0
1
In the present study, we investigated the genetic association between polymorphisms in the insulin receptor INSR gene and PCOS.A total of 260 family trios were recruited and performed a family-based analysis to assess linkage and association between four single nucleotide polymorphisms SNPs rs1799817, rs2059807, rs8108622 and rs10500204 of INSR gene and PCOS.Using the transmission disequilibrium test TDT, we failed to find that rs1799817 p = 0.486, rs2059807 p = 0.195, rs8108622 p = 0.866 and rs10500204 p = 1.0 were significantly overtransmitted to PCOS offspring from their parents.No significant evidence of association or linkage was found in the four tested markers, indicating that our family samples did not support susceptibility of the INSR gene to PCOS.
A common variant in the adiponectin gene and polycystic ovary syndrome risk.
2011-06-03
0.006
1.93
9
However, the ADIPOQ rs2241766 "TT" genotype compared with "TG and GG" genotypes was associated with a 1.93-fold increased risk for PCOS P = 0.006, OR = 1.93, 95% CI = 1.20-3.11, and the differences remained significant after adjustment for age and BMI P = 0.039, OR = 1.72, 95% CI = 1.03-2.86.
A common variant in the adiponectin gene and polycystic ovary syndrome risk.
2011-06-03
0.039
1.72
9
However, the ADIPOQ rs2241766 "TT" genotype compared with "TG and GG" genotypes was associated with a 1.93-fold increased risk for PCOS P = 0.006, OR = 1.93, 95% CI = 1.20-3.11, and the differences remained significant after adjustment for age and BMI P = 0.039, OR = 1.72, 95% CI = 1.03-2.86.
A common variant in the adiponectin gene and polycystic ovary syndrome risk.
2011-06-03
0.006
1.80
9
Furthermore, the ADIPOQ rs2241766 "T" allele was significantly overrepresented in women with PCOS than controls P = 0.006; OR = 1.80, 95% CI = 1.18-2.70, and the difference remained significant after Bonferroni correction.
Harnessing expression data to identify novel candidate genes in polycystic ovary syndrome.
2011-05-17
0.0035
2
We found that no single nucleotide polymorphisms were associated with PCOS risk; however, the major allele of rs1569198 from DKK1 was associated with increased total testosterone discovery cohort P = 0.0035 and dehydroepiandrosterone sulfate replication cohort P = 0.05.
Harnessing expression data to identify novel candidate genes in polycystic ovary syndrome.
2011-05-17
0.05
2
We found that no single nucleotide polymorphisms were associated with PCOS risk; however, the major allele of rs1569198 from DKK1 was associated with increased total testosterone discovery cohort P = 0.0035 and dehydroepiandrosterone sulfate replication cohort P = 0.05.
Harnessing expression data to identify novel candidate genes in polycystic ovary syndrome.
2011-05-17
0.003
4
Minor allele carriers at rs3962158 from DNAJB1 had increased fasting insulin discovery cohort P = 0.003, increased HOMA-IR discovery cohort P = 0.006; replication cohort P = 0.036, and increased HOMA-%B discovery cohort P = 0.004.
Harnessing expression data to identify novel candidate genes in polycystic ovary syndrome.
2011-05-17
0.006
4
Minor allele carriers at rs3962158 from DNAJB1 had increased fasting insulin discovery cohort P = 0.003, increased HOMA-IR discovery cohort P = 0.006; replication cohort P = 0.036, and increased HOMA-%B discovery cohort P = 0.004.
Harnessing expression data to identify novel candidate genes in polycystic ovary syndrome.
2011-05-17
0.036
4
Minor allele carriers at rs3962158 from DNAJB1 had increased fasting insulin discovery cohort P = 0.003, increased HOMA-IR discovery cohort P = 0.006; replication cohort P = 0.036, and increased HOMA-%B discovery cohort P = 0.004.
Harnessing expression data to identify novel candidate genes in polycystic ovary syndrome.
2011-05-17
0.004
4
Minor allele carriers at rs3962158 from DNAJB1 had increased fasting insulin discovery cohort P = 0.003, increased HOMA-IR discovery cohort P = 0.006; replication cohort P = 0.036, and increased HOMA-%B discovery cohort P = 0.004.